The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions.
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Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosisPotent Reversible Inhibition of Myeloperoxidase by Aromatic HydroxamatesMolecular features determining lymphocyte reactivity in allergic contact dermatitis to chloramphenicol and azidamphenicol.Immune response to xenobiotics in the skin: from contact sensitivity to drug allergy.Investigating the mechanisms of aromatic amine-induced protein free radical formation by quantitative structure-activity relationships: implications for drug-induced agranulocytosis.Molecular mechanisms of the conjugated alpha,beta-unsaturated carbonyl derivatives: relevance to neurotoxicity and neurodegenerative diseases.Clozapine-induced agranulocytosis and its genetic determinants.Procainamide, but not N-acetylprocainamide, induces protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis.Spleen-specific development of germinal centers in rats treated with antithyroid drugs.The generation, detection, and effects of reactive drug metabolites.Unexpected hematologic effects of biotherapeutics in nonclinical species and in humans.Current understanding of the mechanisms of idiosyncratic drug-induced agranulocytosis.Bioactivation, protein haptenation, and toxicity of sulfamethoxazole and dapsone in normal human dermal fibroblasts.Reactions of oxidatively activated arylamines with thiols: reaction mechanisms and biologic implications. An overview.Predictive immunotoxicological test systems: suitability of the popliteal lymph node assay in mice and rats.Drug metabolism: from experiments to regulatory aspects.Recognizing idiosyncratic adverse drug reactions in children: A practice imperative.Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity.Potential clozapine target sites on peripheral hematopoietic cells and stromal cells of the bone marrow.Superoxide-dependent oxidation of melatonin by myeloperoxidase.
P2860
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P2860
The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions.
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1992 nî lūn-bûn
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1992年の論文
@ja
1992年学术文章
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1992年学术文章
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1992年学术文章
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1992年学术文章
@zh-my
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@zh-sg
1992年學術文章
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1992年學術文章
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name
The role of leukocyte-generate ...... idiosyncratic drug reactions.
@ast
The role of leukocyte-generate ...... idiosyncratic drug reactions.
@en
type
label
The role of leukocyte-generate ...... idiosyncratic drug reactions.
@ast
The role of leukocyte-generate ...... idiosyncratic drug reactions.
@en
prefLabel
The role of leukocyte-generate ...... idiosyncratic drug reactions.
@ast
The role of leukocyte-generate ...... idiosyncratic drug reactions.
@en
P2860
P1476
The role of leukocyte-generate ...... idiosyncratic drug reactions.
@en
P2093
Uetrecht JP
P2860
P304
P356
10.3109/03602539208996297
P407
P577
1992-01-01T00:00:00Z