Mechanistic studies of semicarbazone triapine targeting human ribonucleotide reductase in vitro and in mammalian cells: tyrosyl radical quenching not involving reactive oxygen species.
about
Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA ReplicationIron chelators in photodynamic therapy revisited: synergistic effect by novel highly active thiosemicarbazones.Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesisRibonucleotide reductase metallocofactor: assembly, maintenance and inhibition.Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes.Strong effect of copper(II) coordination on antiproliferative activity of thiosemicarbazone-piperazine and thiosemicarbazone-morpholine hybrids.Synthesis, DNA Binding, and Antiproliferative Activity of Novel Acridine-Thiosemicarbazone DerivativesClawing back: broadening the notion of metal chelators in medicineCladribine and Fludarabine Nucleotides Induce Distinct Hexamers Defining a Common Mode of Reversible RNR Inhibition.Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance CircumventionTargeting ribonucleotide reductase for cancer therapy.Thioredoxin and glutaredoxin-mediated redox regulation of ribonucleotide reductase.Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies.Intracellular reduction/activation of a disulfide switch in thiosemicarbazone iron chelatorsTargeting RRM2 and Mutant BRAF Is a Novel Combinatorial Strategy for Melanoma.Sirtuin inhibitor sirtinol is an intracellular iron chelator.Disulfide-masked iron prochelators: Effects on cell death, proliferation, and hemoglobin production.Piperazinyl fragment improves anticancer activity of Triapine.
P2860
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P2860
Mechanistic studies of semicarbazone triapine targeting human ribonucleotide reductase in vitro and in mammalian cells: tyrosyl radical quenching not involving reactive oxygen species.
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
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2012年學術文章
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name
Mechanistic studies of semicar ...... lving reactive oxygen species.
@ast
Mechanistic studies of semicar ...... lving reactive oxygen species.
@en
type
label
Mechanistic studies of semicar ...... lving reactive oxygen species.
@ast
Mechanistic studies of semicar ...... lving reactive oxygen species.
@en
prefLabel
Mechanistic studies of semicar ...... lving reactive oxygen species.
@ast
Mechanistic studies of semicar ...... lving reactive oxygen species.
@en
P2093
P2860
P356
P1476
Mechanistic studies of semicar ...... lving reactive oxygen species.
@en
P2093
JoAnne Stubbe
Marcus J C Long
P2860
P304
35768-35778
P356
10.1074/JBC.M112.396911
P407
P577
2012-08-22T00:00:00Z