Inducible dimerization of FGFR1: development of a mouse model to analyze progressive transformation of the mammary gland.
about
Activation of MTK1/MEKK4 by GADD45 through induced N-C dissociation and dimerization-mediated trans autophosphorylation of the MTK1 kinase domainFGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancerFGFR1 is an adverse outcome indicator for luminal A breast cancers.FGF ligands of the postnatal mammary stroma regulate distinct aspects of epithelial morphogenesis.Signalling pathways implicated in early mammary gland morphogenesis and breast cancer.Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions.A Versatile Tumor Gene Deletion System Reveals a Crucial Role for FGFR1 in Breast Cancer Metastasis.p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice.A structure-guided approach to creating covalent FGFR inhibitorsSpatio-temporally precise activation of engineered receptor tyrosine kinases by light.Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer.Fibroblast growth factor receptor 1 activation in mammary tumor cells promotes macrophage recruitment in a CX3CL1-dependent mannerThe FGF/FGFR axis as a therapeutic target in breast cancer.CCAAT/enhancer-binding protein beta: its role in breast cancer and associations with receptor tyrosine kinases.Modulation of fibroblast growth factor signaling is essential for mammary epithelial morphogenesis.Alteration of mammary gland development and gene expression by in utero exposure to arsenicFGFR4 and its novel splice form in myogenic cells: Interplay of glycosylation and tyrosine phosphorylation.Mammary tumorigenesis induced by fibroblast growth factor receptor 1 requires activation of the epidermal growth factor receptor.FGFR1 amplification in breast carcinomas: a chromogenic in situ hybridisation analysis.Aberrant activation of NF-κB signaling in mammary epithelium leads to abnormal growth and ductal carcinoma in situ.FGFR1 Amplification Is Often Homogeneous and Strongly Linked to the Squamous Cell Carcinoma Subtype in Esophageal CarcinomaOptogenetic Control of Fibroblast Growth Factor Receptor Signaling.Expression and regulation of the zinc finger transcription factor Churchill during zebrafish development.A Geometrically-Constrained Mathematical Model of Mammary Gland Ductal Elongation Reveals Novel Cellular Dynamics within the Terminal End Bud.Combination of Sleeping Beauty transposition and chemically induced dimerization selection for robust production of engineered cells.Challenges and opportunities in the targeting of fibroblast growth factor receptors in breast cancer.Upregulation of EGFR signaling is correlated with tumor stroma remodeling and tumor recurrence in FGFR1-driven breast cancer.Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3D mammary epithelial cell model.Characterization of PAR1 and FGFR1 expression in invasive breast carcinomas: Prognostic significance.Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1.Macrophages promote fibroblast growth factor receptor-driven tumor cell migration and invasion in a CXCR2-dependent manner.Chemical genetic screen reveals a role for desmosomal adhesion in mammary branching morphogenesis.Fibroblast growth factor receptor-1 protein expression is associated with prognosis in estrogen receptor-positive/human epidermal growth factor receptor-2-negative primary breast cancer.FGFR1 is amplified during the progression of in situ to invasive breast carcinomaOncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation.Regulation of EphB2 activation and cell repulsion by feedback control of the MAPK pathway.Interleukin-1beta and fibroblast growth factor receptor 1 cooperate to induce cyclooxygenase-2 during early mammary tumourigenesisFibroblast growth factor receptor 1 promotes proliferation and survival via activation of the mitogen-activated protein kinase pathway in bladder cancer.Activation of the FGFR-STAT3 pathway in breast cancer cells induces a hyaluronan-rich microenvironment that licenses tumor formation.Growth factors as active participants in carcinogenesis: a perspective.
P2860
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P2860
Inducible dimerization of FGFR1: development of a mouse model to analyze progressive transformation of the mammary gland.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Inducible dimerization of FGFR ...... ormation of the mammary gland.
@ast
Inducible dimerization of FGFR ...... ormation of the mammary gland.
@en
type
label
Inducible dimerization of FGFR ...... ormation of the mammary gland.
@ast
Inducible dimerization of FGFR ...... ormation of the mammary gland.
@en
prefLabel
Inducible dimerization of FGFR ...... ormation of the mammary gland.
@ast
Inducible dimerization of FGFR ...... ormation of the mammary gland.
@en
P2093
P2860
P356
P1476
Inducible dimerization of FGFR ...... ormation of the mammary gland.
@en
P2093
Alejandro Contreras
Bryan E Welm
David M Spencer
Jeffrey M Rosen
Kevin W Freeman
Mercy Chen
P2860
P304
P356
10.1083/JCB.200107119
P407
P577
2002-05-13T00:00:00Z