Estimating the selective effects of heterozygous protein-truncating variants from human exome data.
about
Negative selection in humans and fruit flies involves synergistic epistasis.The population genetics of human disease: The case of recessive, lethal mutations.Human gene essentiality.A literature review at genome scale: improving clinical variant assessment.Prevalence of loss-of-function alleles does not correlate with lifetime fecundity and other life-history traits in metazoans.Distinct epigenomic patterns are associated with haploinsufficiency and predict risk genes of developmental disorders.Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits
P2860
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P2860
Estimating the selective effects of heterozygous protein-truncating variants from human exome data.
description
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name
Estimating the selective effec ...... ariants from human exome data.
@ast
Estimating the selective effec ...... ariants from human exome data.
@en
type
label
Estimating the selective effec ...... ariants from human exome data.
@ast
Estimating the selective effec ...... ariants from human exome data.
@en
prefLabel
Estimating the selective effec ...... ariants from human exome data.
@ast
Estimating the selective effec ...... ariants from human exome data.
@en
P2093
P2860
P50
P356
P1433
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Estimating the selective effec ...... variants from human exome data
@en
P2093
Christopher A Cassa
Daniel G MacArthur
Daniel J Balick
David R Beier
Donate Weghorn
Shamil R Sunyaev
P2860
P2888
P304
P356
10.1038/NG.3831
P407
P577
2017-04-03T00:00:00Z