Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4
about
An integrative computational systems biology approach identifies differentially regulated dynamic transcriptome signatures which drive the initiation of human T helper cell differentiationCharged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12Requirements for interleukin-4-induced gene expression and functional characterization of Stat6Janus kinases in immune cell signalingSelective regulatory function of Socs3 in the formation of IL-17-secreting T cellsA single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9Selective expression of an interleukin-12 receptor component by human T helper 1 cellsTreatment of experimental (Trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-beta1 plasmid: TGF-beta1-mediated suppression of T helper cell type 1 response occurs by interleukin (IL)-10 inductionHlx homeobox transcription factor negatively regulates interferon-gamma production in monokine-activated natural killer cellsThe Complex Role of STAT3 in Viral InfectionsT Helper Subsets, Peripheral Plasticity, and the Acute Phase Protein, α1-AntitrypsinUpregulation of SOCS-3 and PIAS-3 Impairs IL-12-Mediated Interferon-Gamma Response in CD56+ T Cells in HCV-Infected Heroin UsersUrokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cellsPIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4Recent advances in the genetics of autoimmune diseaseInterleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR)Identification of a STAT4 binding site in the interleukin-12 receptor required for signalingDifferential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinasesSingle dose intranasal administration of retinal autoantigen generates a rapid accumulation and cell activation in draining lymph node and spleen: implications for tolerance therapyProteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitisEngineering an effective immune adjuvant by designed control of shape and crystallinity of aluminum oxyhydroxide nanoparticlesImpairment of natural killer cytotoxic activity and interferon gamma production in CCAAT/enhancer binding protein gamma-deficient miceCyclin G associated kinase interacts with interleukin 12 receptor beta2 and suppresses interleukin 12 induced IFN-gamma productionSTAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferationThe transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gammaRecruitment of Stat4 to the human interferon-alpha/beta receptor requires activated Stat2Age-dependent maturation of Toll-like receptor-mediated cytokine responses in Gambian infantsOpposing roles of STAT4 and Dnmt3a in Th1 gene regulationDefective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient miceAntigen-independent IFN-γ production by human naïve CD4 T cells activated by IL-12 plus IL-18IL-18-stimulated GADD45 beta required in cytokine-induced, but not TCR-induced, IFN-gamma production.IL-12 as a therapeutic target for pharmacological modulation in immune-mediated and inflammatory diseases: regulation of T helper 1/T helper 2 responsesc-jun controls the ability of IL-12 to induce IL-10 production from human memory CD4+ T cellsPathways of T cell pathology in models of chronic intestinal inflammation.Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection.STAT4 is required for antibacterial defense but enhances mortality during polymicrobial sepsis.Dendritic cell regulation of TH1-TH2 development.Interleukin (IL)-12 receptor beta1 or IL-12 receptor beta 2 deficiency in mice indicates that IL-12 and IL-23 are not essential for host recovery from viral encephalitis.Impact of microbes on autoimmune diseases.IL-12 is required for mTOR regulation of memory CTLs during viral infection.
P2860
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P2860
Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Interleukin 12 signaling in T ...... ranscription (Stat)3 and Stat4
@ast
Interleukin 12 signaling in T ...... ranscription (Stat)3 and Stat4
@en
type
label
Interleukin 12 signaling in T ...... ranscription (Stat)3 and Stat4
@ast
Interleukin 12 signaling in T ...... ranscription (Stat)3 and Stat4
@en
prefLabel
Interleukin 12 signaling in T ...... ranscription (Stat)3 and Stat4
@ast
Interleukin 12 signaling in T ...... ranscription (Stat)3 and Stat4
@en
P2093
P2860
P356
P1476
Interleukin 12 signaling in T ...... ranscription (Stat)3 and Stat4
@en
P2093
J E Darnell
K M Murphy
N G Jacobson
R D Schreiber
R M Weber-Nordt
P2860
P304
P356
10.1084/JEM.181.5.1755
P407
P577
1995-05-01T00:00:00Z