A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi
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Trypanocidal drugs for late stage, symptomatic Chagas disease (Trypanosoma cruzi infection)Enzymes of the cyclooxygenase pathways of prostanoid biosynthesisBioactive lipids in Trypanosoma cruzi infectionLipid Body Organelles within the Parasite Trypanosoma cruzi: A Role for Intracellular Arachidonic Acid MetabolismMetabolic signatures of triatomine vectors of Trypanosoma cruzi unveiled by metabolomicsBenznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomicsActivation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in LeishmaniaDrug resistance in eukaryotic microorganisms.Aspirin treatment of mice infected with Trypanosoma cruzi and implications for the pathogenesis of Chagas diseaseAntichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme.Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs.Structure of the inhibitor complex of old yellow enzyme from Trypanosoma cruziEvaluating 5-nitrofurans as trypanocidal agents.Production of eicosanoids and other oxylipins by pathogenic eukaryotic microbes.Target validation: linking target and chemical properties to desired product profileThromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection.A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes.Preparation, crystallization and preliminary crystallographic analysis of old yellow enzyme from Trypanosoma cruziIdentification of a functional prostanoid-like receptor in the protozoan parasite, Trypanosoma cruzi.Putative Role of the Aldo-Keto Reductase from Trypanosoma cruzi in Benznidazole Metabolism.Comprehensive genome-wide analysis reveals different classes of enigmatic old yellow enzyme in fungiTrypanocidal drugs: mechanisms, resistance and new targets.eIF2 kinases mediate β-lapachone toxicity in yeast and human cancer cells.The role of laccase in prostaglandin production by Cryptococcus neoformans.Gene expression study using real-time PCR identifies an NTR gene as a major marker of resistance to benzonidazole in Trypanosoma cruziRole of cyclooxygenase-2 in Trypanosoma cruzi survival in the early stages of parasite host-cell interactionTranscriptome and Functional Genomics Reveal the Participation of Adenine Phosphoribosyltransferase in Trypanosoma cruzi Resistance to Benznidazole.Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population.Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs.Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole.Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites.Suppression of adipocyte differentiation by aldo-keto reductase 1B3 acting as prostaglandin F2alpha synthase.Antiparasitic prodrug nifurtimox: revisiting its activation mechanism.Reduction of quinones by NADH catalyzed by organoiridium complexes.Engineering towards nitroreductase functionality in ene-reductase scaffolds.Comparative characterization and expression analysis of the four Old Yellow Enzyme homologues from Shewanella oneidensis indicate differences in physiological function.Cryptococcus neoformans produces authentic prostaglandin E2 without a cyclooxygenase.Nitro-fatty acid metabolome: saturation, desaturation, beta-oxidation, and protein adduction.Prostaglandin F2α synthase in Trypanosoma cruzi plays critical roles in oxidative stress and susceptibility to benznidazole.Ligand-induced conformational changes in the capping subdomain of a bacterial old yellow enzyme homologue and conserved sequence fingerprints provide new insights into substrate binding.
P2860
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P2860
A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi
@ast
A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi
@en
type
label
A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi
@ast
A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi
@en
prefLabel
A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi
@ast
A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi
@en
P2093
P2860
P50
P356
P1476
A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi
@en
P2093
Bruno Kilunga Kubata
Craig J Munday
Michael Duszenko
Samuel K Martin
Shunichi Fukuzumi
Toshihiko Maruyama
Yoshihiro Urade
Zakayi Kabututu
P2860
P304
P356
10.1084/JEM.20020885
P407
P577
2002-11-01T00:00:00Z