Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells. - Test2 - elhamkhani - TriplyDB

Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells.

Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells.

http://www.wikidata.org/entity/Q36378260

about

Down syndrome and leukemia: insights into leukemogenesis and translational targets The biology of pediatric acute megakaryoblastic leukemia Concise Review: Methods and Cell Types Used to Generate Down Syndrome Induced Pluripotent Stem Cells Modelling human disease with pluripotent stem cells The emerging role of GATA transcription factors in development and disease A System to Study Aneuploidy In Vivo Transient Abnormal Myelopoiesis and AML in Down Syndrome: an Update Heterozygous and homozygous JAK2(V617F) states modeled by induced pluripotent stem cells from myeloproliferative neoplasm patients Impaired hematopoietic differentiation of RUNX1-mutated induced pluripotent stem cells derived from FPD/AML patients.Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia.GATA factor mutations in hematologic disease.The prenatal origins of cancer Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells.Deficits in human trisomy 21 iPSCs and neurons.Integrated differential transcriptome maps of Acute Megakaryoblastic Leukemia (AMKL) in children with or without Down Syndrome (DS)Pluripotent stem cells reveal erythroid-specific activities of the GATA1 N-terminus.Donor Dependent Variations in Hematopoietic Differentiation among Embryonic and Induced Pluripotent Stem Cell Lines.Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21 Spontaneous ATM Gene Reversion in A-T iPSC to Produce an Isogenic Cell Line.Myeloid Proliferations Associated with Down Syndrome.Brief report: isogenic induced pluripotent stem cell lines from an adult with mosaic down syndrome model accelerated neuronal ageing and neurodegeneration.Chromosome transplantation as a novel approach for correcting complex genomic disorders Uniparental disomy of the entire X chromosome in Turner syndrome patient-specific induced pluripotent stem cells Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic leukemia Induced pluripotent stem cells as a cellular model for studying Down Syndrome.Genomic instability in pluripotent stem cells: implications for clinical applications.GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia.Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells.Generation of iPS cells from normal and malignant hematopoietic cells.The impact of trisomy 21 on foetal haematopoiesis.Modeling neurodevelopmental disorders using human pluripotent stem cells.Haematopoietic development and leukaemia in Down syndrome.Stem and progenitor cell dysfunction in human trisomies.Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells.Aneuploid embryonic stem cells exhibit impaired differentiation and increased neoplastic potential.Generation of Integration-Free Induced Pluripotent Stem Cells from Urine-Derived Cells Isolated from Individuals with Down Syndrome.Evolution of myeloid leukemia in children with Down syndrome.Down syndrome and the complexity of genome dosage imbalance.Molecular Characterization of Down Syndrome Embryonic Stem Cells Reveals a Role for RUNX1 in Neural Differentiation.

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Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells.

http://www.wikidata.org/entity/Q36378260

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2012 nî lūn-bûn

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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Altered hematopoiesis in triso ...... genic human pluripotent cells.

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Altered hematopoiesis in triso ...... genic human pluripotent cells.

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Altered hematopoiesis in triso ...... genic human pluripotent cells.

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Altered hematopoiesis in triso ...... genic human pluripotent cells.

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Proceedings of the National Academy of Sciences of the United States of America

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Altered hematopoiesis in triso ...... genic human pluripotent cells.

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Danielle J Sanchez

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In-Hyun Park

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Tobias F Menne

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P2860

Production of embryonic and fetal-like red blood cells from human induced pluripotent stem cells

Disease-specific induced pluripotent stem cells

Myeloid leukemia in Down syndrome

Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21

Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst

Incidence and clinical implications of GATA1 mutations in newborns with Down syndrome

Developmental and species-divergent globin switching are driven by BCL11A

Treatment and prognostic impact of transient leukemia in neonates with Down syndrome

Hematological disorders and leukemia in children with Down syndrome.

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