about
Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTOThe AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNACharacterization of a novel DNA glycosylase from S. sahachiroi involved in the reduction and repair of azinomycin B induced DNA damageCrystal structure of the RNA demethylase ALKBH5 from zebrafishSwitching demethylation activities between AlkB family RNA/DNA demethylases through exchange of active-site residuesImposing function down a (cupin)-barrel: secondary structure and metal stereochemistry in the αKG-dependent oxygenases.A proteome chip approach reveals new DNA damage recognition activities in Escherichia coliThe fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice.Targeting and processing of site-specific DNA interstrand crosslinks.Insight into the cooperative DNA binding of the O⁶-alkylguanine DNA alkyltransferase.Repair of DNA Alkylation Damage by the Escherichia coli Adaptive Response Protein AlkB as Studied by ESI-TOF Mass Spectrometry.Quantifying the energetic contributions of desolvation and π-electron density during translesion DNA synthesis.Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5Exploring the roles of nucleobase desolvation and shape complementarity during the misreplication of O(6)-methylguanine.Mechanism of S-oxygenation by a cysteine dioxygenase model complexExocyclic carbons adjacent to the N6 of adenine are targets for oxidation by the Escherichia coli adaptive response protein AlkB.DNA Polymerases ImuC and DinB Are Involved in DNA Alkylation Damage Tolerance in Pseudomonas aeruginosa and Pseudomonas putidaAxial and equatorial ligand effects on biomimetic cysteine dioxygenase model complexesRhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA DamageUsing the bias from flow to elucidate single DNA repair protein sliding and interactions with DNA.New insights into estrogenic regulation of O6-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O6-benzylguanine indicates fresh avenues for therapy.Genome dynamics in major bacterial pathogens.Investigating the biochemical impact of DNA damage with structure-based probes: abasic sites, photodimers, alkylation adducts, and oxidative lesions.Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage.Copper carbenes alkylate guanine chemoselectively through a substrate directed reaction.Quantum mechanics/molecular mechanics study on the oxygen binding and substrate hydroxylation step in AlkB repair enzymesZinc finger proteins as templates for metal ion exchange and ligand reactivity. Chemical and biological consequences.Abnormalities of DNA repair mechanisms in common hematological malignancies.Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools.Genome stability: recent insights in the topoisomerase reverse gyrase and thermophilic DNA alkyltransferase.Mechanistic studies on the application of DNA aptamers as inhibitors of 2-oxoglutarate-dependent oxygenases.Quantum Mechanics/Molecular Mechanics Modeling of Enzymatic Processes: Caveats and Breakthroughs.Protein sensing in living cells by molecular rotor-based fluorescence-switchable chemical probesOligodeoxynucleotides containing N1-methyl-2'-deoxyadenosine and N6-methyl-2'-deoxyadenosine.Properties and reactivities of nonheme iron(IV)-oxo versus iron(V)-oxo: long-range electron transfer versus hydrogen atom abstraction.Every OGT Is Illuminated … by Fluorescent and Synchrotron Lights.Temozolomide-perillyl alcohol conjugate downregulates O6-methylguanin DNA methltransferase via inducing ubiquitination-dependent proteolysis in non-small cell lung cancer.A simple but effective modeling strategy for structural properties of non-heme Fe(II) sites in proteins: test of force field models and application to proteins in the AlkB family.Can the peroxosuccinate complex in the catalytic cycle of taurine/alpha-ketoglutarate dioxygenase (TauD) act as an alternative oxidant?Applications of Potential Energy Surfaces in the Study of Enzymatic Reactions
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Direct reversal of DNA alkylation damage.
@ast
Direct reversal of DNA alkylation damage.
@en
type
label
Direct reversal of DNA alkylation damage.
@ast
Direct reversal of DNA alkylation damage.
@en
prefLabel
Direct reversal of DNA alkylation damage.
@ast
Direct reversal of DNA alkylation damage.
@en
P2093
P2860
P356
P1433
P1476
Direct reversal of DNA alkylation damage.
@en
P2093
Erica M Duguid
Yukiko Mishina
P2860
P304
P356
10.1021/CR0404702
P577
2006-02-01T00:00:00Z