Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis - Test2 - elhamkhani - TriplyDB

Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis

Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis

http://www.wikidata.org/entity/Q36391968

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Mouse Models Recapitulating Human Adrenocortical Tumors: What Is Lacking?Functional Zonation of the Adult Mammalian Adrenal Cortex Zona glomerulosa cells of the mouse adrenal cortex are intrinsic electrical oscillators.Mechanisms mediating environmental chemical-induced endocrine disruption in the adrenal gland Primary Aldosteronism: Changing Definitions and New Concepts of Physiology and Pathophysiology Both Inside and Outside the Kidney.Variant Discovery and Fine Mapping of Genetic Loci Associated with Blood Pressure Traits in Hispanics and African Americans KCNK3 Variants Are Associated With Hyperaldosteronism and Hypertension.Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold.Variations in the potassium channel genes KCNK3 and KCNK9 in relation to blood pressure and aldosterone production: an exploratory study TASK-3 channel deletion in mice recapitulates low-renin essential hypertension.Role of K(+) channels in the pathophysiology of primary aldosteronism.TASK channels are not required to mount an aldosterone secretory response to metabolic acidosis in mice.TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system.Emerging roles for two-pore-domain potassium channels and their potential therapeutic impact.Cooperative endocytosis of the endosomal SNARE protein syntaxin-8 and the potassium channel TASK-1.Minireview: potassium channels and aldosterone dysregulation: is primary aldosteronism a potassium channelopathy?NGS nominated CELA1, HSPG2, and KCNK5 as candidate genes for predisposition to Balkan endemic nephropathy Membrane potential depolarization as a triggering mechanism for Vpu-mediated HIV-1 release.The role of TASK1 in aldosterone production and its expression in normal adrenal and aldosterone-producing adenomas.Uncoupling of secretion from growth in some hormone secretory tissues.Genetic variations in the KCNJ5 gene in primary aldosteronism patients from Xinjiang, China Identification of SPRED2 (sprouty-related protein with EVH1 domain 2) as a negative regulator of the hypothalamic-pituitary-adrenal axis.Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels.Understanding primary aldosteronism: impact of next generation sequencing and expression profiling.Aldosterone stimulates superoxide production in macula densa cells Two-pore domain potassium channels in the adrenal cortex.Acute and chronic regulation of aldosterone production.Molecular and Cellular Mechanisms of Aldosterone Producing Adenoma Development Potassium channels related to primary aldosteronism: Expression similarities and differences between human and rat adrenals.Potassium channel mutant KCNJ5 T158A expression in HAC-15 cells increases aldosterone synthesis.Mouse models of adrenocortical tumors.Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis Ion channels as novel therapeutic targets in the treatment of pain.Molecular physiology of pH-sensitive background K(2P) channels.The genetic basis of primary aldosteronism.Role of KCNJ5 in familial and sporadic primary aldosteronism.Regulation of aldosterone biosynthesis by the Kir3.4 (KCNJ5) potassium channel.Steroidogenesis-adrenal cell signal transduction.Regulation of aldosterone synthesis and secretion.Pathophysiology, diagnosis, and treatment of mineralocorticoid disorders.

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P2860

Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis

http://www.wikidata.org/entity/Q36391968

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2007 nî lūn-bûn

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2007年學術文章

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2007年學術文章

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Invalidation of TASK1 potassiu ...... mineralocorticoid homeostasis

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Invalidation of TASK1 potassiu ...... mineralocorticoid homeostasis

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Invalidation of TASK1 potassiu ...... mineralocorticoid homeostasis

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Invalidation of TASK1 potassiu ...... mineralocorticoid homeostasis

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Invalidation of TASK1 potassiu ...... mineralocorticoid homeostasis

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Invalidation of TASK1 potassiu ...... mineralocorticoid homeostasis

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SJ.EMBOJ.7601934

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The EMBO Journal

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Invalidation of TASK1 potassiu ...... mineralocorticoid homeostasis

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Achim Weber

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Celso E Gomez-Sanchez

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Christina Sterner

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Dirk Heitzmann

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Frank Schweda

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Ines Tegtmeier

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Jacques Barhanin

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Markus Reichold

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Nicolas Guy

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Raymond Mengual

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P2860

Expression pattern in brain of TASK-1, TASK-3, and a tandem pore domain K(+) channel subunit, TASK-5, associated with the central auditory nervous system

Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase

The regulation of aldosterone synthase expression

Motoneurons express heteromeric TWIK-related acid-sensitive K+ (TASK) channels containing TASK-1 (KCNK3) and TASK-3 (KCNK9) subunits

Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice

Molecular and functional properties of two-pore-domain potassium channels.

Functional expression of TASK-1/TASK-3 heteromers in cerebellar granule cells.

Investigating mineralocorticoid hypertension.

Control of aldosterone secretion: a model for convergence in cellular signaling pathways.

Glucocorticoid-suppressible hyperaldosteronism and adrenal tumors occurring in a single French pedigree.

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