Allosteric voltage gating of potassium channels II. Mslo channel gating charge movement in the absence of Ca(2+).
about
Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertensionGating mechanism of BK (Slo1) channels: so near, yet so farInactivation of BK channels mediated by the NH(2) terminus of the beta3b auxiliary subunit involves a two-step mechanism: possible separation of binding and blockadeGating properties conferred on BK channels by the beta3b auxiliary subunit in the absence of its NH(2)- and COOH terminiBeta1 subunits facilitate gating of BK channels by acting through the Ca2+, but not the Mg2+, activating mechanismsBK channels: multiple sensors, one activation gateDihydroxyeicosatrienoic acids are potent activators of Ca(2+)-activated K(+) channels in isolated rat coronary arterial myocytesSteady-state and closed-state inactivation properties of inactivating BK channelsPresynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels.Alpha5beta1 integrin engagement increases large conductance, Ca2+-activated K+ channel current and Ca2+ sensitivity through c-src-mediated channel phosphorylation.A BK (Slo1) channel journey from molecule to physiology.Operation of the voltage sensor of a human voltage- and Ca2+-activated K+ channel.Location of modulatory beta subunits in BK potassium channels.Coupling and cooperativity in voltage activation of a limited-state BK channel gating in saturating Ca2+.Cryo-EM structure of the open high-conductance Ca2+-activated K+ channelHigh temperature sensitivity is intrinsic to voltage-gated potassium channels.Stepwise contribution of each subunit to the cooperative activation of BK channels by Ca2+.CDK5 interacts with Slo and affects its surface expression and kinetics through direct phosphorylationBK channel activation: structural and functional insightsComplex voltage-dependent behavior of single unliganded calcium-sensitive potassium channels.Modeling hair cell tuning by expression gradients of potassium channel beta subunits.Inhibition of large-conductance Ca2+-activated K+ channels by nanomolar concentrations of Ag+.A self-consistent approach for determining pairwise interactions that underlie channel activation.Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism.Large conductance, Ca2+-activated K+ channels (BKCa) and arteriolar myogenic signalingVoltage- and cold-dependent gating of single TRPM8 ion channels.β4-subunit increases Slo responsiveness to physiological Ca2+ concentrations and together with β1 reduces surface expression of Slo in hair cellsSetting the stage for molecular dissection of the regulatory components of BK channels.Single-channel kinetics of BK (Slo1) channels.Voltage-dependent conformational changes in human Ca(2+)- and voltage-activated K(+) channel, revealed by voltage-clamp fluorometry.Charge substitution for a deep-pore residue reveals structural dynamics during BK channel gating.Mg(2+) binding to open and closed states can activate BK channels provided that the voltage sensors are elevatedEstimating the voltage-dependent free energy change of ion channels using the median voltage for activationThe LRRC26 protein selectively alters the efficacy of BK channel activators.Allosteric modulation of ion channels: the case of maxi-K.Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations.Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels.Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channelsMultiple facets of maxi-k+ channels: the heme connection.Direct observation of a preinactivated, open state in BK channels with beta2 subunits
P2860
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P2860
Allosteric voltage gating of potassium channels II. Mslo channel gating charge movement in the absence of Ca(2+).
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Allosteric voltage gating of p ...... ment in the absence of Ca(2+).
@ast
Allosteric voltage gating of p ...... ment in the absence of Ca(2+).
@en
type
label
Allosteric voltage gating of p ...... ment in the absence of Ca(2+).
@ast
Allosteric voltage gating of p ...... ment in the absence of Ca(2+).
@en
prefLabel
Allosteric voltage gating of p ...... ment in the absence of Ca(2+).
@ast
Allosteric voltage gating of p ...... ment in the absence of Ca(2+).
@en
P2860
P356
P1476
Allosteric voltage gating of p ...... ment in the absence of Ca(2+).
@en
P2093
F T Horrigan
R W Aldrich
P2860
P304
P356
10.1085/JGP.114.2.305
P577
1999-08-01T00:00:00Z