Protein kinase activation increases insulin secretion by sensitizing the secretory machinery to Ca2+.
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TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cellsMechanisms of action of glucagon-like peptide 1 in the pancreasPancreatic regulation of glucose homeostasisCyclic AMP dynamics in the pancreatic β-cellInsulin secretion: a high-affinity Ca2+ sensor after all?Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variantsExocytosis, Endocytosis, and Their Coupling in Excitable Cells.PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.Cyclic AMP potentiates Ca2+-dependent exocytosis in pancreatic duct epithelial cells.Possible protective effect of membrane lipid rafts against interleukin-1β-mediated anti-proliferative effect in INS-1 cells.Lessons from models of pancreatic beta cells for engineering glucose-sensing cellsContribution of protein kinase Cα in the stimulation of insulin by the down-regulation of Cavβ subunits.Activators of PKA and Epac distinctly influence insulin secretion and cytosolic Ca2+ in female mouse islets stimulated by glucose and tolbutamide.Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of LangerhansMunc18-1 and Munc18-2 proteins modulate beta-cell Ca2+ sensitivity and kinetics of insulin exocytosis differently.Evolving insights regarding mechanisms for the inhibition of insulin release by norepinephrine and heterotrimeric G proteins.Phosphomimetic mutation of Ser-187 of SNAP-25 increases both syntaxin binding and highly Ca2+-sensitive exocytosis.Ca2+-secretion coupling is impaired in diabetic Goto Kakizaki ratsPKC-induced sensitization of Ca2+-dependent exocytosis is mediated by reducing the Ca2+ cooperativity in pituitary gonadotropes.A highly Ca2+-sensitive pool of granules is regulated by glucose and protein kinases in insulin-secreting INS-1 cellsAstrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretionPI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets.Newcomer insulin secretory granules as a highly calcium-sensitive poolGnRH-Induced Ca(2+) Signaling Patterns and Gonadotropin Secretion in Pituitary Gonadotrophs. Functional Adaptations to Both Ordinary and Extraordinary Physiological Demands.Long-term exposure to genistein improves insulin secretory function of pancreatic beta-cells.Contributions of mathematical modeling of beta cells to the understanding of beta-cell oscillations and insulin secretionMolecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells.Modes of exocytosis and electrogenesis underlying canine biphasic insulin secretion.Excitable Astrocytes: Ca(2+)- and cAMP-Regulated Exocytosis.On depolarization-evoked exocytosis as a function of calcium entry: possibilities and pitfalls.Exocytosis in non-neuronal cells.Free Fatty Acid Receptor 1 (FFAR1) as an Emerging Therapeutic Target for Type 2 Diabetes Mellitus: Recent Progress and Prevailing Challenges.cAMP signalling in insulin and glucagon secretion.Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM.Short-term potentiation of membrane resealing in neighboring cells is mediated by purinergic signaling.Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM.Mathematical modeling of insulin secretion and the role of glucose-dependent mobilization, docking, priming and fusion of insulin granules.A subcellular model of glucose-stimulated pancreatic insulin secretion.Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic beta cells.
P2860
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P2860
Protein kinase activation increases insulin secretion by sensitizing the secretory machinery to Ca2+.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
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2004年學術文章
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name
Protein kinase activation incr ...... e secretory machinery to Ca2+.
@ast
Protein kinase activation incr ...... e secretory machinery to Ca2+.
@en
type
label
Protein kinase activation incr ...... e secretory machinery to Ca2+.
@ast
Protein kinase activation incr ...... e secretory machinery to Ca2+.
@en
prefLabel
Protein kinase activation incr ...... e secretory machinery to Ca2+.
@ast
Protein kinase activation incr ...... e secretory machinery to Ca2+.
@en
P2093
P2860
P356
P1476
Protein kinase activation incr ...... e secretory machinery to Ca2+.
@en
P2093
Jiuping Ding
Qun-Fang Wan
Xuelin Lou
Yongming Dong
P2860
P304
P356
10.1085/JGP.200409082
P577
2004-12-01T00:00:00Z