Molecular switch for CLC-K Cl- channel block/activation: optimal pharmacophoric requirements towards high-affinity ligands
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Chloride channels as drug targets.Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug DiscoveryThe Concise Guide to PHARMACOLOGY 2013/14: ion channelsFlufenamic acid as an ion channel modulator.An optical assay of the transport activity of ClC-7.Physiology and pathophysiology of ClC-K/barttin channels.Structure-activity relationship of fenamates as Slo2.1 channel activators.A designed inhibitor of a CLC antiporter blocks function through a unique binding mode.Ion channels in renal disease.Discovery of potent CLC chloride channel inhibitors.Novel diuretic targetsCell biology and physiology of CLC chloride channels and transporters.Structure and function of the thin limbs of the loop of Henle.In silico model of the human ClC-Kb chloride channel: pore mapping, biostructural pathology and drug screening.Alkaline pH block of CLC-K kidney chloride channels mediated by a pore lysine residue.Statins and fibrate target ClC-1 - from side effects to CLC pharmacologyA regulatory calcium-binding site at the subunit interface of CLC-K kidney chloride channels.Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels.Molecular Pharmacology of Kidney and Inner Ear CLC-K Chloride Channels.Niflumic acid alters gating of HCN2 pacemaker channels by interaction with the outer region of S4 voltage sensing domains.Functional characterization of ClC-1 mutations from patients affected by recessive myotonia congenita presenting with different clinical phenotypes.A selective class of inhibitors for the CLC-Ka chloride ion channel.Pharmacovigilance database search discloses ClC-K channels as a novel target of the AT1 receptor blockers valsartan and olmesartan.
P2860
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P2860
Molecular switch for CLC-K Cl- channel block/activation: optimal pharmacophoric requirements towards high-affinity ligands
description
2008 nî lūn-bûn
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2008年の論文
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2008年学术文章
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2008年学术文章
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2008年学术文章
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2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
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name
Molecular switch for CLC-K Cl- ...... towards high-affinity ligands
@ast
Molecular switch for CLC-K Cl- ...... towards high-affinity ligands
@en
type
label
Molecular switch for CLC-K Cl- ...... towards high-affinity ligands
@ast
Molecular switch for CLC-K Cl- ...... towards high-affinity ligands
@en
prefLabel
Molecular switch for CLC-K Cl- ...... towards high-affinity ligands
@ast
Molecular switch for CLC-K Cl- ...... towards high-affinity ligands
@en
P2093
P2860
P356
P1476
Molecular switch for CLC-K Cl- ...... towards high-affinity ligands
@en
P2093
Alessandra Picollo
Antonella Liantonio
Diana Conte Camerino
Elena Babini
Fulvio Loiodice
Giovanni Zifarelli
Giuseppe Carbonara
Giuseppe Fracchiolla
Michael Pusch
Paolo Tortorella
P2860
P304
P356
10.1073/PNAS.0708977105
P407
P577
2008-01-23T00:00:00Z