Specific protein domains mediate cooperative assembly of HuR oligomers on AU-rich mRNA-destabilizing sequences. - Test2 - elhamkhani - TriplyDB

Specific protein domains mediate cooperative assembly of HuR oligomers on AU-rich mRNA-destabilizing sequences.

Specific protein domains mediate cooperative assembly of HuR oligomers on AU-rich mRNA-destabilizing sequences.

http://www.wikidata.org/entity/Q36463009

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RNA-binding protein HuR autoregulates its expression by promoting alternative polyadenylation site usage Posttranslational control of HuR function Post-transcriptional control of gene expression by AUF1: mechanisms, physiological targets, and regulation Leukocyte protease binding to nucleic acids promotes nuclear localization and cleavage of nucleic acid binding proteins A novel high throughput biochemical assay to evaluate the HuR protein-RNA complex formation The export receptor Crm1 forms a dimer to promote nuclear export of HIV RNA Folate receptor-targeted nanoparticle delivery of HuR-RNAi suppresses lung cancer cell proliferation and migration An oocyte-specific ELAVL2 isoform is a translational repressor ablated from meiotically competent antral oocytes The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro.Tandem phosphorylation of serines 221 and 318 by protein kinase Cdelta coordinates mRNA binding and nucleocytoplasmic shuttling of HuR.The RNA binding protein HuR does not interact directly with HIV-1 reverse transcriptase and does not affect reverse transcription in vitro.Functional characterization of the HuR:CD83 mRNA interaction.Regulation of nucleolin expression by miR-194, miR-206, and HuR.A 1536-well fluorescence polarization assay to screen for modulators of the MUSASHI family of RNA-binding proteins.Coordinated expression of tristetraprolin post-transcriptionally attenuates mitogenic induction of the oncogenic Ser/Thr kinase Pim-1.Different modes of interaction by TIAR and HuR with target RNA and DNA Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability Identification and validation of novel small molecule disruptors of HuR-mRNA interaction.Balanced splicing at the Tat-specific HIV-1 3'ss A3 is critical for HIV-1 replication Identification of Small-Molecule Inhibitors of the HuR/RNA Interaction Using a Fluorescence Polarization Screening Assay Followed by NMR Validation HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA.Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination The C-terminal RNA binding motif of HuR is a multi-functional domain leading to HuR oligomerization and binding to U-rich RNA targets.mRNA and DNA selection via protein multimerization: YB-1 as a case study.RNA-binding protein HuR mediates cytoprotection through stimulation of XIAP translation.Hsp70 is a novel posttranscriptional regulator of gene expression that binds and stabilizes selected mRNAs containing AU-rich elements.The third RNA recognition motif of Drosophila ELAV protein has a role in multimerization.Role of transcription factor Sp1 and RNA binding protein HuR in the downregulation of Dr+ Escherichia coli receptor protein decay accelerating factor (DAF or CD55) by nitric oxide Hyper conserved elements in vertebrate mRNA 3'-UTRs reveal a translational network of RNA-binding proteins controlled by HuR.All three RNA recognition motifs and the hinge region of HuC play distinct roles in the regulation of alternative splicing.The p97-UBXD8 complex destabilizes mRNA by promoting release of ubiquitinated HuR from mRNP Cleavage and polyadenylation specificity factor 30: An RNA-binding zinc-finger protein with an unexpected 2Fe-2S cluster.Distinct binding properties of TIAR RRMs and linker region.Mutant copper-zinc superoxide dismutase associated with amyotrophic lateral sclerosis binds to adenine/uridine-rich stability elements in the vascular endothelial growth factor 3'-untranslated region.Diverse molecular functions of Hu proteins.Assembly of functional ribonucleoprotein complexes by AU-rich element RNA-binding protein 1 (AUF1) requires base-dependent and -independent RNA contacts.The RNA stability regulator HuR regulates L1 protein expression in vivo in differentiating cervical epithelial cells.The complex world of post-transcriptional mechanisms: is their deregulation a common link for diseases? Focus on ELAV-like RNA-binding proteins.Trans-acting factors governing acetylcholinesterase mRNA metabolism in neurons.Mechanisms coordinating ELAV/Hu mRNA regulons.

P2860

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P2860

Specific protein domains mediate cooperative assembly of HuR oligomers on AU-rich mRNA-destabilizing sequences.

http://www.wikidata.org/entity/Q36463009

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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2007年學術文章

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name

Specific protein domains media ...... mRNA-destabilizing sequences.

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Specific protein domains media ...... mRNA-destabilizing sequences.

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type

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Specific protein domains media ...... mRNA-destabilizing sequences.

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Specific protein domains media ...... mRNA-destabilizing sequences.

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prefLabel

Specific protein domains media ...... mRNA-destabilizing sequences.

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Specific protein domains media ...... mRNA-destabilizing sequences.

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Journal of Biological Chemistry

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Specific protein domains media ...... mRNA-destabilizing sequences.

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P2093

Brandy Y Brewer

http://www.w3.org/2001/XMLSchema#string

Chris D Willis

http://www.w3.org/2001/XMLSchema#string

Elizabeth J Fialcowitz-White

http://www.w3.org/2001/XMLSchema#string

Eric A Toth

http://www.w3.org/2001/XMLSchema#string

Gerald M Wilson

http://www.w3.org/2001/XMLSchema#string

Jeff D Ballin

http://www.w3.org/2001/XMLSchema#string

P2860

HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA

AU binding proteins recruit the exosome to degrade ARE-containing mRNAs

Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin

AU-rich elements and associated factors: are there unifying principles?

Highly selective actions of HuR in antagonizing AU-rich element-mediated mRNA destabilization

NMR studies on functional structures of the AU-rich element-binding domains of Hu antigen C

Structural basis for recognition of AU-rich element RNA by the HuD protein

Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein

Delineation of mRNA export pathways by the use of cell-permeable peptides

A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery

P304

20948-20959

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scholarly article

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10.1074/JBC.M701751200

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29

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282

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2007-05-21T00:00:00Z

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17517897

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2244793

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