Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitro.
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Impact of Chromatin on HIV ReplicationDNA minicircles clarify the specific role of DNA structure on retroviral integrationStructural and Histone Binding Ability Characterizations of Human PWWP DomainsStructural basis for high-affinity binding of LEDGF PWWP to mononucleosomesFunctional coupling between HIV-1 integrase and the SWI/SNF chromatin remodeling complex for efficient in vitro integration into stable nucleosomesSUMOylation of the lens epithelium-derived growth factor/p75 attenuates its transcriptional activity on the heat shock protein 27 promoter.TOX4 and NOVA1 proteins are partners of the LEDGF PWWP domain and affect HIV-1 replicationIntasome architecture and chromatin density modulate retroviral integration into nucleosomeRepair of oxidative DNA base damage in the host genome influences the HIV integration site sequence preference.Retroviral integration site selection.FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75.DNA Physical Properties and Nucleosome Positions Are Major Determinants of HIV-1 Integrase SelectivityRole of the PWWP domain of lens epithelium-derived growth factor (LEDGF)/p75 cofactor in lentiviral integration targetingHost Factors in Retroviral Integration and the Selection of Integration Target Sites.Sites of retroviral DNA integration: From basic research to clinical applicationsIdentification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity.Menin critically links MLL proteins with LEDGF on cancer-associated target genesIn search of small molecules blocking interactions between HIV proteins and intracellular cofactors.Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex.Alternative splicing and caspase-mediated cleavage generate antagonistic variants of the stress oncoprotein LEDGF/p75.In search of second-generation HIV integrase inhibitors: targeting integration beyond strand transfer.HIV-1 Integrase-DNA Recognition Mechanisms.The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional InsightsMind the methyl: methyllysine binding proteins in epigenetic regulation.Molecular mechanisms of MLL-associated leukemia.Modulation of chromatin structure by the FACT histone chaperone complex regulates HIV-1 integration.Different Pathways Leading to Integrase Inhibitors ResistanceHIV-1 integrase modulates the interaction of the HIV-1 cellular cofactor LEDGF/p75 with chromatin.Peptides derived from the HIV-1 integrase promote HIV-1 infection and multi-integration of viral cDNA in LEDGF/p75-knockdown cells.Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: insight into integrase-DNA complex formation and catalysis.Modulation of the functional association between the HIV-1 intasome and the nucleosome by histone amino-terminal tails.Cellular and molecular mechanisms of HIV-1 integration targeting.Nup153 Unlocks the Nuclear Pore Complex for HIV-1 Nuclear Translocation in Non-dividing CellsStructure, mechanics, and binding mode heterogeneity of LEDGF/p75–DNA nucleoprotein complexes revealed by scanning force microscopy
P2860
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P2860
Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitro.
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2008 nî lūn-bûn
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2008年の論文
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2008年論文
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2008年論文
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2008年論文
@zh-hk
2008年論文
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2008年論文
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2008年论文
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2008年论文
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name
Chromatinized templates reveal ...... ng HIV-1 integration in vitro.
@ast
Chromatinized templates reveal ...... ng HIV-1 integration in vitro.
@en
type
label
Chromatinized templates reveal ...... ng HIV-1 integration in vitro.
@ast
Chromatinized templates reveal ...... ng HIV-1 integration in vitro.
@en
prefLabel
Chromatinized templates reveal ...... ng HIV-1 integration in vitro.
@ast
Chromatinized templates reveal ...... ng HIV-1 integration in vitro.
@en
P2093
P2860
P356
P1476
Chromatinized templates reveal ...... ng HIV-1 integration in vitro.
@en
P2093
Alan Engelman
Marc Lavigne
Nidhanapati K Raghavendra
Shaila Rahman
Yaïr Botbol
P2860
P304
P356
10.1093/NAR/GKM1127
P407
P577
2008-01-03T00:00:00Z