Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease - Test2 - elhamkhani - TriplyDB

Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease

Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease

http://www.wikidata.org/entity/Q36514979

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The balance of powers: Redox regulation of fibrogenic pathways in kidney injury Targeting Mitochondria and Reactive Oxygen Species-Driven Pathogenesis in Diabetic Nephropathy Obesity and Diabetic Kidney Disease: Role of Oxidant Stress and Redox Balance Systems biology analysis reveals role of MDM2 in diabetic nephropathy Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease.Antioxidant treatment attenuates lactate production in diabetic nephropathy.Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats.Metabolomics in diabetic complications.Tissue-specific metabolic reprogramming drives nutrient flux in diabetic complications Diabetes and Kidney Disease: Role of Oxidative Stress.Inhibition of the processing of miR-25 by HIPK2-Phosphorylated-MeCP2 induces NOX4 in early diabetic nephropathy.Sustained kidney biochemical derangement in treated experimental diabetes: a clue to metabolic memory.Advanced Glycation End-Products Induce Apoptosis of Vascular Smooth Muscle Cells: A Mechanism for Vascular Calcification.Metabolomics for clinical use and research in chronic kidney disease.Canonical Transient Receptor Potential 6 Channel: A New Target of Reactive Oxygen Species in Renal Physiology and Pathology.An overview of renal metabolomics.Therapeutic potential of NADPH oxidase 1/4 inhibitors.NADPH Oxidase 4 at the Nexus of Diabetes, Reactive Oxygen Species, and Renal Metabolism.Myeloperoxidase Activity and Oxidized Amino Acids as Biomarkers in Chronic Kidney Disease and Coronary Artery Disease.Mitochondrial Dysfunction in the Diabetic Kidney.Hydrogen sulfide inhibits high glucose-induced NADPH oxidase 4 expression and matrix increase by recruiting inducible nitric oxide synthase in kidney proximal tubular epithelial cells.NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis and Bioenergetics in Lung Fibroblasts via a Nuclear Factor Erythroid-derived 2-like 2 (Nrf2)-dependent Pathway.A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models.Modelling diabetic nephropathy in mice.Tyrosines-740/751 of PDGFRβ contribute to the activation of Akt/Hif1α/TGFβ nexus to drive high glucose-induced glomerular mesangial cell hypertrophy.Elevation of fumarase attenuates hypertension and can result from a nonsynonymous sequence variation or increased expression depending on rat strain.Metabolomics window into diabetic complications.Urinary exosomes as a novel biomarker for evaluation of α-lipoic acid's protective effect in early diabetic nephropathy.Bottom-up proteomics analysis of the secretome of murine islets of Langerhans in elevated glucose levels.Glomerular Endothelial Cells Stress and Cross-Talk With Podocytes in the Development of Diabetic Kidney Disease.The Warburg Effect in Diabetic Kidney Disease.Early Growth Response 1 (Egr1) Is a Transcriptional Activator of NOX4 in Oxidative Stress of Diabetic Kidney Disease.Comprehensive renoprotective effects of ipragliflozin on early diabetic nephropathy in mice.Network analysis of membranous glomerulonephritis based on metabolomics data Serum metabolites are associated with all-cause mortality in chronic kidney disease

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P2860

Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease

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2015年论文

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2015年论文

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Journal of the American Society of Nephrology

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Metabolomics Reveals a Key Rol ...... e 4 in Diabetic Kidney Disease

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Jessica Pham

http://www.w3.org/2001/XMLSchema#string

Kumar Sharma

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Rintaro Saito

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Tammy Quach

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Young-Hyun You

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P2860

Identification of renox, an NAD(P)H oxidase in kidney

Adiponectin regulates albuminuria and podocyte function in mice

NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells

Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

Hypoxia-inducible factors in the kidney

Decreased complex II respiration and HNE-modified SDH subunit in diabetic heart

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy.

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466-481

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10.1681/ASN.2015030302

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2

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27

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2015-07-22T00:00:00Z

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4731129

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