Opening Pandora's jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders.
about
Neuronal networks in mental diseases and neuropathic pain: Beyond brain derived neurotrophic factor and collapsin response mediator proteinsMoving towards effective therapeutic strategies for Neuronal Ceroid LipofuscinosisAlternative functions of the brain transsulfuration pathway represent an underappreciated aspect of brain redox biochemistry with significant potential for therapeutic engagementSpecific binding of lacosamide to collapsin response mediator protein 2 (CRMP2) and direct impairment of its canonical function: implications for the therapeutic potential of lacosamideCytoskeletal regulation dominates temperature-sensitive proteomic changes of hibernation in forebrain of 13-lined ground squirrelsA cell-penetrating ester of the neural metabolite lanthionine ketimine stimulates autophagy through the mTORC1 pathway: Evidence for a mechanism of action with pharmacological implications for neurodegenerative pathologiesALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the diseaseCollapsin response mediator protein 2: high-resolution crystal structure sheds light on small-molecule binding, post-translational modifications, and conformational flexibility.Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2.Calpain-mediated cleavage of collapsin response mediator protein-2 drives acute axonal degenerationEstrogen deficiency is associated with hippocampal morphological remodeling of early postmenopausal miceROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS.The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowthNovel monoclonal antibodies to study tissue regeneration in planarians.Redox regulation of autophagy in healthy brain and neurodegeneration.SUMOylation alters CRMP2 regulation of calcium influx in sensory neurons.Collapsin Response Mediator Protein-2 (CRMP2) is a Plausible Etiological Factor and Potential Therapeutic Target in Alzheimer's Disease: Comparison and Contrast with Microtubule-Associated Protein TauCRMP2 protein SUMOylation modulates NaV1.7 channel trafficking.Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with β-amyloid burden and synaptic deficits in Lewy body dementiasCollapsin response mediator protein 2 (CRMP2) interacts with N-methyl-D-aspartate (NMDA) receptor and Na+/Ca2+ exchanger and regulates their functional activity.CRMP2: functional roles in neural development and therapeutic potential in neurological diseases.The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue.Transcriptional regulation of CRMP5 controls neurite outgrowth through Sox5.Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential.A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors.Synaptoproteomic analysis of a rat gene-environment model of depression reveals involvement of energy metabolism and cellular remodeling pathways.Effects of Gualou Guizhi Decoction Aqueous Extract on Axonal Regeneration in Organotypic Cortical Slice Culture after Oxygen-Glucose Deprivation.Lanthionine ketimine ester provides benefit in a mouse model of multiple sclerosis.Proteomic analysis of six- and twelve-month hippocampus and cerebellum in a murine Down syndrome model.Association between DPYSL2 gene polymorphisms and alcohol dependence in Caucasian samples.A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function.(S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5.Quantitative expression proteomics and phosphoproteomics profile of brain from PINK1 knockout mice: insights into mechanisms of familial Parkinson's disease.Lanthionine ketimine ethyl ester partially rescues neurodevelopmental defects in unc-33 (DPYSL2/CRMP2) mutants.Quantitative phosphoproteomic analyses of the inferior parietal lobule from three different pathological stages of Alzheimer's disease.Phosphorylation, Dephosphorylation, and Multiprotein Assemblies Regulate Dynamic Behavior of Neuronal Cytoskeleton: A Mini-ReviewCRMP2 and voltage-gated ion channels: potential roles in neuropathic pain
P2860
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P2860
Opening Pandora's jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Opening Pandora's jar: a prime ...... neuron, and central disorders.
@ast
Opening Pandora's jar: a prime ...... neuron, and central disorders.
@en
type
label
Opening Pandora's jar: a prime ...... neuron, and central disorders.
@ast
Opening Pandora's jar: a prime ...... neuron, and central disorders.
@en
prefLabel
Opening Pandora's jar: a prime ...... neuron, and central disorders.
@ast
Opening Pandora's jar: a prime ...... neuron, and central disorders.
@en
P2093
P2860
P356
P1433
P1476
Opening Pandora's jar: a prime ...... neuron, and central disorders
@en
P2093
Allan Butterfield
Jill Weimer
Joel M Brittain
Kenneth Hensley
Rukhsana Sultana
Sarah M Wilson
P2860
P304
P356
10.2217/FNL.12.68
P577
2012-11-01T00:00:00Z