Immunohistochemical loss of succinate dehydrogenase subunit A (SDHA) in gastrointestinal stromal tumors (GISTs) signals SDHA germline mutation - Test2 - elhamkhani - TriplyDB

Immunohistochemical loss of succinate dehydrogenase subunit A (SDHA) in gastrointestinal stromal tumors (GISTs) signals SDHA germline mutation

Immunohistochemical loss of succinate dehydrogenase subunit A (SDHA) in gastrointestinal stromal tumors (GISTs) signals SDHA germline mutation

http://www.wikidata.org/entity/Q36532675

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Post-transcriptional dysregulation by miRNAs is implicated in the pathogenesis of gastrointestinal stromal tumor [GIST]SDHA mutations causing a multisystem mitochondrial disease: novel mutations and genetic overlap with hereditary tumors Syndromic gastrointestinal stromal tumors Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics Novel uses of immunohistochemistry in the diagnosis and classification of soft tissue tumors Connecting molecular pathways to hereditary cancer risk syndromes Molecular subtypes of gastrointestinal stromal tumors and their prognostic and therapeutic implications.SDHA related tumorigenesis: a new case series and literature review for variant interpretation and pathogenicity.The progressive fragmentation of the KIT/PDGFRA wild-type (WT) gastrointestinal stromal tumors (GIST)Succinate dehydrogenase deficient gastrointestinal stromal tumors (GISTs) - a review.Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST).MDCT features of succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumours.Succinate dehydrogenase (SDH)-deficient renal carcinoma: a morphologically distinct entity: a clinicopathologic series of 36 tumors from 27 patients.Sarcoma classification: an update based on the 2013 World Health Organization Classification of Tumors of Soft Tissue and Bone.Succinate dehydrogenase-deficient gastrointestinal stromal tumors.A new bispecific antibody targeting non-overlapping epitopes on IGF2: design, in vitro characterization and pharmacokinetics in macaques A multicenter phase II study of pazopanib in patients with advanced gastrointestinal stromal tumors (GIST) following failure of at least imatinib and sunitinib.Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumors (GIST).Targeting cancer metabolism.A novel germline mutation in SDHA identified in a rare case of gastrointestinal stromal tumor complicated with renal cell carcinoma.The genetic landscape of gastrointestinal stromal tumor lacking KIT and PDGFRA mutations.Succinate dehydrogenase deficiency in pediatric and adult gastrointestinal stromal tumors.Succinate dehydrogenase expression in breast cancer.Gastrointestinal stromal tumors: management of metastatic disease and emerging therapies.Succinate dehydrogenase deficiency is rare in pituitary adenomas.Novel pathways and molecular targets for the treatment of sarcoma.An overview on molecular biology of KIT/PDGFRA wild type (WT) gastrointestinal stromal tumours (GIST).Gastrointestinal stromal tumours: from KIT to succinate dehydrogenase.Newly available antibodies with practical applications in surgical pathology.Gastrointestinal stromal tumors: what do we know now?Toward an improved definition of the genetic and tumor spectrum associated with SDH germ-line mutations.Clinicopathologic study of succinate-dehydrogenase-deficient gastrointestinal stromal tumors: A single-institutional experience in China The emerging role and targetability of the TCA cycle in cancer metabolism.Biochemical, Molecular, and Clinical Characterization of Succinate Dehydrogenase Subunit A Variants of Unknown Significance."Wild type" GIST: Clinicopathological features and clinical practice.Gastrointestinal stromal tumors (GISTs): SEAP-SEOM consensus on pathologic and molecular diagnosis.P16 overexpression in BRAF-mutated gastrointestinal stromal tumors.Using molecular diagnostic testing to personalize the treatment of patients with gastrointestinal stromal tumors.Functional Effects of Cigarette Smoke-Induced Changes in Airway Smooth Muscle Mitochondrial Morphology.

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P2860

Immunohistochemical loss of succinate dehydrogenase subunit A (SDHA) in gastrointestinal stromal tumors (GISTs) signals SDHA germline mutation

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Immunohistochemical loss of su ...... signals SDHA germline mutation

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Immunohistochemical loss of su ...... signals SDHA germline mutation

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Immunohistochemical loss of su ...... signals SDHA germline mutation

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Immunohistochemical loss of su ...... signals SDHA germline mutation

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The American Journal of Surgical Pathology

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Immunohistochemical loss of su ...... signals SDHA germline mutation

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Christopher Lau

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Jerzy Lasota

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Jonathan Keith Killian

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Lee Helman

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Marbin Pineda

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Markku Miettinen

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Paul Meltzer

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Robert Walker

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Su Y Kim

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Yuelin Jack Zhu

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P2860

Leigh syndrome caused by mutations in the flavoprotein (Fp) subunit of succinate dehydrogenase (SDHA)

Immunohistochemistry for SDHB divides gastrointestinal stromal tumors (GISTs) into 2 distinct types

Tumor risks and genotype-phenotype-proteotype analysis in 358 patients with germline mutations in SDHB and SDHD.

SDHA loss-of-function mutations in KIT-PDGFRA wild-type gastrointestinal stromal tumors identified by massively parallel sequencing.

Missense mutations in the NF2 gene result in the quantitative loss of merlin protein and minimally affect protein intrinsic function.

Succinate dehydrogenase - Assembly, regulation and role in human disease.

SDHA is a tumor suppressor gene causing paraganglioma.

SDH mutations in cancer.

Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations.

Clinical and molecular genetics of patients with the Carney-Stratakis syndrome and germline mutations of the genes coding for the succinate dehydrogenase subunits SDHB, SDHC, and SDHD.

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2

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2013-02-01T00:00:00Z

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23282968

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immunohistochemistry

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3545041

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