The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer.
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Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic PotentialMammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget.Tamoxifen Action in ER-Negative Breast Cancer.A Systematic Approach to Preclinical Trials in Metastatic Breast Cancer.Oestrogen receptor negativity in breast cancer: a cause or consequence?Non-immunosuppressive triazole-based small molecule induces anticancer activity against human hormone-refractory prostate cancers: the role in inhibition of PI3K/AKT/mTOR and c-Myc signaling pathwaysMetastatic triple-negative breast cancer is dependent on SphKs/S1P signaling for growth and survival.Modified breast cancer model for preclinical immunotherapy studies.The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases.Sphingosine-1-phosphate modulators in inflammatory skin diseases - lining up for clinical translation.Targeting sphingosine-1-phosphate signaling in lung diseases.Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P) in acute lung injury: Role of S1P lyase.Lipidomics in translational research and the clinical significance of lipid-based biomarkers.S1P promotes breast cancer progression by angiogenesis and lymphangiogenesisFTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts.Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation.Sphingosine kinase 1 in breast cancer.Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer.A genome-wide screen for FTY720-sensitive mutants reveals genes required for ROS homeostasis.The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer.Expansion of Sphingosine Kinase and Sphingosine-1-Phosphate Receptor Function in Normal and Cancer Cells: From Membrane Restructuring to Mediation of Estrogen Signaling and Stem Cell Programming.Targeting the Epigenome as a Novel Therapeutic Approach for Breast Cancer.Nuclear Lipid Mediators: Role of Nuclear Sphingolipids and Sphinosine-1-Phosphate Signaling in Epigenetic Regulation of Inflammation and Gene Expression.Murine breast cancer mastectomy model that predicts patient outcomes for drug development.Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain.More than Just an Immunosuppressant: The Emerging Role of FTY720 as a Novel Inducer of ROS and Apoptosis.Regulatory role of sphingosine kinase and sphingosine-1-phosphate receptor signaling in progenitor/stem cells
P2860
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P2860
The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
The phosphorylated prodrug FTY ...... nal therapy for breast cancer.
@ast
The phosphorylated prodrug FTY ...... nal therapy for breast cancer.
@en
type
label
The phosphorylated prodrug FTY ...... nal therapy for breast cancer.
@ast
The phosphorylated prodrug FTY ...... nal therapy for breast cancer.
@en
prefLabel
The phosphorylated prodrug FTY ...... nal therapy for breast cancer.
@ast
The phosphorylated prodrug FTY ...... nal therapy for breast cancer.
@en
P2093
P2860
P356
P1433
P1476
The phosphorylated prodrug FTY ...... nal therapy for breast cancer.
@en
P2093
E J Gallagher
M Nagahashi
S Milstien
P2860
P2888
P356
10.1038/ONCSIS.2015.16
P577
2015-06-08T00:00:00Z
P5875
P6179
1011374529