Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining
about
Marine-derived myxobacteria of the suborder Nannocystineae: An underexplored source of structurally intriguing and biologically active metabolites-Genomic data mining of the marine actinobacteria Streptomyces sp. H-KF8 unveils insights into multi-stress related genes and metabolic pathways involved in antimicrobial synthesis.Marine Rare Actinobacteria: Isolation, Characterization, and Strategies for Harnessing Bioactive Compounds.Phylogenomic Insight into Salinispora (Bacteria, Actinobacteria) Species DesignationsInterpreting Microbial Biosynthesis in the Genomic Age: Biological and Practical Considerations.Chemical probing of thiotetronate bio-assembly.The polyketide backbone of thiolactomycin is assembled by an unusual iterative polyketide synthase.Natural product discovery from the human microbiome.Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials.Minimization of the Thiolactomycin Biosynthetic Pathway Reveals that the Cytochrome P450 Enzyme TlmF Is Required for Five-Membered Thiolactone Ring Formation.The Antibiotic Resistant Target Seeker (ARTS), an exploration engine for antibiotic cluster prioritization and novel drug target discovery.Transformation-associated recombination (TAR) cloning for genomics studies and synthetic biology.Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites.Mining prokaryotes for antimicrobial compounds: from diversity to function.The evolution of genome mining in microbes - a review.Toolbox for Antibiotics Discovery from Microorganisms.Antibiotic drug discovery.Natural Products and the Gene Cluster Revolution.Challenges and opportunities for whole-genome sequencing-based surveillance of antibiotic resistance.Breaking the silence: new strategies for discovering novel natural products.Finding a helix in a haystack: nucleic acid cytometry with droplet microfluidics.Genomic insights into specialized metabolism in the marine actinomycete Salinispora.Opportunities for natural products in 21st century antibiotic discovery.Sequencing rare marine actinomycete genomes reveals high density of unique natural product biosynthetic gene clusters.Evidence for an iterative module in chain elongation on the azalomycin polyketide synthase.Broad-Host-Range Expression Reveals Native and Host Regulatory Elements That Influence Heterologous Antibiotic Production in Gram-Negative BacteriaGenerate a bioactive natural product library by mining bacterial cytochrome P450 patterns.GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection.Biosynthetic Pathway Connects Cryptic Ribosomally Synthesized Posttranslationally Modified Peptide Genes with Pyrroloquinoline Alkaloids.PCR-Independent Method of Transformation-Associated Recombination Reveals the Cosmomycin Biosynthetic Gene Cluster in an Ocean Streptomycete.Actinomycetes: still a source of novel antibiotics.Development of fungal cell factories for the production of secondary metabolites: Linking genomics and metabolism.Enzymatic C-H Oxidation-Amidation Cascade in the Production of Natural and Unnatural Thiotetronate Antibiotics with Potentiated Bioactivity.Self-resistance guided genome mining uncovers new topoisomerase inhibitors from myxobacteria.Computational Methodologies in the Exploration of Marine Natural Product LeadsThe impact and prospect of natural product discovery in agriculture: New technologies to explore the diversity of secondary metabolites in plants and microorganisms for applications in agricultureResistance-gene-directed discovery of a natural-product herbicide with a new mode of action
P2860
Q26747261-DE1AADC8-A3B6-4098-8F73-F22124CF4AE3Q31164981-74C5A232-BACA-4305-AB8D-9442E0B97BA1Q33799744-8CEF8E19-D638-49A4-8FA8-09640258B015Q33804228-63AFD1E8-97F7-4D14-9195-33B461E020B6Q33833366-E030AF3A-5F6A-4104-AB10-2DE81AFF789EQ36259328-053B2598-5162-4C21-A5C4-85E8C6E98F97Q36260641-59F01375-B229-479D-ADD7-BB0DB3561676Q36340566-9DDC4993-C3B8-4B08-8FDD-C4FB407F3062Q38636716-28537373-0BB0-4C68-8B5F-056AEC9CFAB4Q38732664-5D7269C6-E3BC-48BA-8785-EC88514D95D1Q38803944-E8C04716-7BB9-499C-9CA4-E8DC6BE43B83Q38817999-8AB04F00-AE5F-4291-8DF5-8B50BA27B38CQ38823592-503DEE96-C020-42B5-8ABC-6CC6C2330D8FQ38840658-634C3793-359E-4587-83CD-CF9B95614B6AQ38858040-9B165032-2C7A-4C06-AECC-CE64F8F978F8Q38867326-926554FA-07F4-42C9-886F-56F93820C4BAQ38912113-B45D7F50-4A6F-4E3B-AB90-2FDB06D0224FQ38918786-DED8885D-C3A9-4101-8A40-02DC1B478840Q38992444-79775057-B8FB-42CC-94BA-C0C6ED334734Q39176174-7BBFA57B-C6AC-427F-B412-6DA978DD46ADQ39328378-37AFFFA8-8E4F-4F1B-8FEC-4FFF7281E7FEQ40115761-426FF84E-A271-4EDC-B701-166A81CA7A08Q40189627-FAC0E9FB-0FF9-4AB0-94F0-F1E6665A2CB1Q40429748-6FE7F0E0-3396-4ADB-AB6B-3E111893A560Q41594005-E9262934-19BF-4A97-90E5-6E9631A39D80Q41622407-3BC2418A-DD3F-425B-B255-B8455875A1F2Q45269243-F7CCA366-1D37-42B0-8E7D-50A824E94F13Q45335732-D0BC272F-5012-4E1D-8232-271DECCFC487Q45967009-45B839A2-D902-42FA-9424-3BA98C19BDA9Q46040715-E3F8A933-FB16-4BFF-AF45-5126561DCD6CQ46319269-B08F4F21-83F8-46FC-8278-A77CC53143F6Q46809688-31539F55-6555-4712-878C-5ACF84D9DEAFQ47325183-0B7155A5-A89D-49AA-A82D-1D0E1BE6CC7DQ55404502-84BB82F3-8BB0-4979-B957-F63629DE5702Q57001336-D4694E63-9CC9-4143-9ECC-D1E7E39F2A9DQ58550293-49719B87-3E61-404A-86F1-E10F574FF746Q59064103-7C468170-88E6-417B-82C1-42C7DD1A8BB1
P2860
Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Identification of Thiotetronic ...... Target-directed Genome Mining
@ast
Identification of Thiotetronic ...... Target-directed Genome Mining
@en
type
label
Identification of Thiotetronic ...... Target-directed Genome Mining
@ast
Identification of Thiotetronic ...... Target-directed Genome Mining
@en
prefLabel
Identification of Thiotetronic ...... Target-directed Genome Mining
@ast
Identification of Thiotetronic ...... Target-directed Genome Mining
@en
P2093
P2860
P50
P1433
P1476
Identification of Thiotetronic ...... Target-directed Genome Mining
@en
P2093
Jia Jia Zhang
Natalie Millán-Aguiñaga
Simone M Mantovani
P2860
P304
P356
10.1021/ACSCHEMBIO.5B00658
P577
2015-10-12T00:00:00Z