Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB.
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T cell receptor signalling in the control of regulatory T cell differentiation and functionThe Contribution of Chemokines and Migration to the Induction of Central Tolerance in the ThymusMaturation and migration of murine CD4 single positive thymocytes and thymic emigrantsPositive and negative selection of the T cell repertoire: what thymocytes see (and don't see)Distinct temporal patterns of T cell receptor signaling during positive versus negative selection in situDistinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns.Revisiting thymic positive selection and the mature T cell repertoire for antigen.Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cellsConcomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naïve mice.The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function.Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.Thymic low affinity/avidity interaction selects natural Th1 cellsDifferences in Expression Level of Helios and Neuropilin-1 Do Not Distinguish Thymus-Derived from Extrathymically-Induced CD4+Foxp3+ Regulatory T Cells.Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells.Alternative Splice Variants Modulates Dominant-Negative Function of Helios in T-Cell Leukemia.Pathogenic Transdifferentiation of Th17 Cells Contribute to Perpetuation of Rheumatoid Arthritis during Anti-TNF Treatment.TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors.An Essential Role for the Transcription Factor Runx1 in T Cell MaturationDynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla.Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes.Maturation and emigration of single-positive thymocytes.Thymic development of autoreactive T cells in NOD mice is regulated in an age-dependent mannerNdfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells.The role of CARMA1 in T cells.Phenotypic alterations, clinical impact and therapeutic potential of regulatory T cells in cancer.The checkpoint for agonist selection precedes conventional selection in human thymus.T-cell selection in the thymus: a spatial and temporal perspective.The Autoimmunity-Associated Gene CLEC16A Modulates Thymic Epithelial Cell Autophagy and Alters T Cell Selection.Redox balance of mouse medullary CD4 single-positive thymocytes.Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis.Cell death and thymic tolerance.The Role of the Ikaros Family of Transcription Factors in Regulatory T cell Development and Function.c-REL and IκBNS Govern Common and Independent Steps of Regulatory T Cell Development from Novel CD122-Expressing Pre-Precursors.IL-2 prevents deletion of developing T-regulatory cells in the thymus.Safety and efficacy of allogeneic hematopoietic stem cell transplant after PD-1 blockade in relapsed/refractory lymphoma.Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCRβ Repertoire.A Zap70-dependent feedback circuit is essential for efficient selection of CD4 lineage thymocytes.Transcription factor c-Rel is indispensable for generation of thymic but not of peripheral Foxp3+ regulatory T cells.Crossreactive αβ T Cell Receptors Are the Predominant Targets of Thymocyte Negative Selection.Monoclonal regulatory T cells provide insights into T cell suppression.
P2860
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P2860
Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Helios marks strongly autoreac ...... by induction of PD-1 or NF-κB.
@ast
Helios marks strongly autoreac ...... by induction of PD-1 or NF-κB.
@en
type
label
Helios marks strongly autoreac ...... by induction of PD-1 or NF-κB.
@ast
Helios marks strongly autoreac ...... by induction of PD-1 or NF-κB.
@en
prefLabel
Helios marks strongly autoreac ...... by induction of PD-1 or NF-κB.
@ast
Helios marks strongly autoreac ...... by induction of PD-1 or NF-κB.
@en
P2860
P356
P1476
Helios marks strongly autoreac ...... by induction of PD-1 or NF-κB
@en
P2093
Daniel Y Hu
P2860
P304
P356
10.1084/JEM.20121458
P407
P577
2013-01-21T00:00:00Z