A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis. - Test2 - elhamkhani - TriplyDB

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis.

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis.

http://www.wikidata.org/entity/Q36617953

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Emerging concepts for PI3K/mTOR inhibition as a potential treatment for osteosarcoma Osteosarcoma: Cells-of-Origin, Cancer Stem Cells, and Targeted Therapies The utility of transposon mutagenesis for cancer studies in the era of genome editing.MicroRNAs and Potential Targets in Osteosarcoma: Review Exploring targeted therapy of osteosarcoma using proteomics data Germline and somatic genetics of osteosarcoma - connecting aetiology, biology and therapy.Osteosarcoma Overview.Rb1 and Pten Co-Deletion in Osteoblast Precursor Cells Causes Rapid Lipoma Formation in Mice.Semaphorin 4D Promotes Skeletal Metastasis in Breast Cancer A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma.RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens Future directions in the treatment of osteosarcoma.Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance.Deciphering signaling networks in osteosarcoma pathobiology.Expression of semaphorin 6D and its receptor plexin-A1 in gastric cancer and their association with tumor angiogenesis.Assessing the Prognostic Significance of Histologic Response in Osteosarcoma: A Comparison of Outcomes on CCG-782 and INT0133-A Report From the Children's Oncology Group Bone Tumor Committee.Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression.Transmembrane semaphorins: Multimodal signaling cues in development and cancer.Heterotypic mouse models of canine osteosarcoma recapitulate tumor heterogeneity and biological behavior.Increased PD-L1 and T-cell infiltration in the presence of HLA class I expression in metastatic high-grade osteosarcoma: a rationale for T-cell-based immunotherapy.The anti-cancer activity of the mTORC1/2 dual inhibitor XL388 in preclinical osteosarcoma models.PPARγ agonists promote differentiation of cancer stem cells by restraining YAP transcriptional activity.Transposon insertional mutagenesis in mice identifies human breast cancer susceptibility genes and signatures for stratification.Sleeping Beauty transposon insertional mutagenesis based mouse models for cancer gene discovery Osteosarcoma: Molecular Pathogenesis and iPSC Modeling.Vectors and strategies for nonviral cancer gene therapy.Wilms' tumor gene 1 silencing inhibits proliferation of human osteosarcoma MG-63 cell line by cell cycle arrest and apoptosis activation.Long noncoding RNA FGFR3-AS1 promotes osteosarcoma growth through regulating its natural antisense transcript FGFR3.Genetic factors conferring metastasis in osteosarcoma.Novel insights and therapeutic interventions for pediatric osteosarcoma.The role of the semaphorins in cancer.Sleeping Beauty transposition: from biology to applications.Molecular genetics of osteosarcoma.Imprinting defects at human 14q32 locus alters gene expression and is associated with the pathobiology of osteosarcoma.miR-200c and phospho-AKT as prognostic factors and mediators of osteosarcoma progression and lung metastasis.Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma.WWOX and p53 Dysregulation Synergize to Drive the Development of Osteosarcoma Coping with cancer genes altered by copy number.

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A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis.

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A Sleeping Beauty forward gene ...... ma development and metastasis.

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A Sleeping Beauty forward gene ...... ma development and metastasis.

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Nature Genetics

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A Sleeping Beauty forward gene ...... ma development and metastasis.

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Aaron L Sarver

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Branden S Moriarity

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Chand Khanna

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Colleen L Forster

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David A Largaespada

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Eric P Rahrmann

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George M Otto

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Kevin J Holly

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Kwangmin Choi

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Luke A Manlove

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Suppression of bone formation by osteoclastic expression of semaphorin 4D

PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice

Evaluation of eIF4E expression in an osteosarcoma-specific tissue microarray

A transposon-based genetic screen in mice identifies genes altered in colorectal cancer

Repression of p53-dependent sequence-specific transactivation by MEF2c

Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

Metastasis: from dissemination to organ-specific colonization

Osteosarcomagenesis: modeling cancer initiation in the mouse.

Novel molecular and computational methods improve the accuracy of insertion site analysis in Sleeping Beauty-induced tumors.

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615-624

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10.1038/NG.3293

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6

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47

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Stephen M. Hewitt

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2015-05-11T00:00:00Z

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1027174885

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25961939

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