Old drug, new target: ellipticines selectively inhibit RNA polymerase I transcription. - Test2 - elhamkhani - TriplyDB

Old drug, new target: ellipticines selectively inhibit RNA polymerase I transcription.

Old drug, new target: ellipticines selectively inhibit RNA polymerase I transcription.

http://www.wikidata.org/entity/Q36620686

about

A survey on the computational approaches to identify drug targets in the postgenomic era First-in-Class Inhibitors of Sulfur Metabolism with Bactericidal Activity against Non-Replicating M. tuberculosis Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia.Nucleolar stress with and without p53.Anticancer Alkaloids from Trees: Development into Drugs.Functional divergence of eukaryotic RNA polymerases: unique properties of RNA polymerase I suit its cellular role The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies: studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN™) mice and pure enzymes.Selective inhibition of rDNA transcription by a small-molecule peptide that targets the interface between RNA polymerase I and Rrn3.Extending in silico mechanism-of-action analysis by annotating targets with pathways: application to cellular cytotoxicity readouts.LKB1 promotes cell survival by modulating TIF-IA-mediated pre-ribosomal RNA synthesis under uridine downregulated conditions Regulation of ribosomal gene expression in cancer.TIF-IA: An oncogenic target of pre-ribosomal RNA synthesis.New roles for Dicer in the nucleolus and its relevance to cancer The identification of a novel role for BRCA1 in regulating RNA polymerase I transcription.Targeting RNA-Polymerase I in Both Chemosensitive and Chemoresistant Populations in Epithelial Ovarian Cancer.N-thioalkylcarbazoles derivatives as new anti-proliferative agents: synthesis, characterisation and molecular mechanism evaluation.Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint.Novel Assay to Detect RNA Polymerase I Activity In Vivo.

P2860

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P2860

Old drug, new target: ellipticines selectively inhibit RNA polymerase I transcription.

http://www.wikidata.org/entity/Q36620686

description

2013 nî lūn-bûn

@nan

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

2013年论文

@zh

2013年论文

@zh-cn

name

Old drug, new target: ellipticines selectively inhibit RNA polymerase I transcription.

@ast

Old drug, new target: ellipticines selectively inhibit RNA polymerase I transcription.

@en

type

label

Old drug, new target: ellipticines selectively inhibit RNA polymerase I transcription.

@ast

Old drug, new target: ellipticines selectively inhibit RNA polymerase I transcription.

@en

prefLabel

Old drug, new target: ellipticines selectively inhibit RNA polymerase I transcription.

@ast

Old drug, new target: ellipticines selectively inhibit RNA polymerase I transcription.

@en

P1433

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P2860

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P932

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P356

JBC.M112.411611

P1433

Journal of Biological Chemistry

P1476

Old drug, new target: ellipticines selectively inhibit RNA polymerase I transcription.

@en

P2093

Christophe Normand

http://www.w3.org/2001/XMLSchema#string

Irina G Tikhonova

http://www.w3.org/2001/XMLSchema#string

Konstantin I Panov

http://www.w3.org/2001/XMLSchema#string

Olivier Gadal

http://www.w3.org/2001/XMLSchema#string

Tatiana Panova

http://www.w3.org/2001/XMLSchema#string

William J Andrews

http://www.w3.org/2001/XMLSchema#string

P2860

Construction, characterization, and complementation of a conditional-lethal DNA topoisomerase IIalpha mutant human cell line

hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters

Casein kinase 2 associates with initiation-competent RNA polymerase I and has multiple roles in ribosomal DNA transcription

RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor

The economics of ribosome biosynthesis in yeast

Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis

UBF levels determine the number of active ribosomal RNA genes in mammals

Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis

Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53

Yeast pre-rRNA processing and modification occur cotranscriptionally

P304

4567-4582

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P31

scholarly article

P356

10.1074/JBC.M112.411611

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P407

P433

7

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P478

288

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P577

2013-01-04T00:00:00Z

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P698

23293027

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P932

3576063

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