Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models.
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Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacyEpoxyeicosatrienoic acids and cardioprotection: the road to translationInhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in miceOral treatment of rodents with soluble epoxide hydrolase inhibitor 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea (TPPU): Resulting drug levels and modulation of oxylipin patternAn omega-3 epoxide of docosahexaenoic acid lowers blood pressure in angiotensin-II-dependent hypertension.Soluble epoxide hydrolase inhibitor, t-TUCB, protects against myocardial ischaemic injury in rats.Soluble epoxide hydrolase inhibition is antinociceptive in a mouse model of diabetic neuropathy.Identification of potent inhibitors of the chicken soluble epoxide hydrolase.Soluble Epoxide Hydrolase Pharmacological Inhibition Ameliorates Experimental Acute Pancreatitis in Mice.Occurrence of urea-based soluble epoxide hydrolase inhibitors from the plants in the order BrassicalesSoluble epoxide hydrolase inhibitor 1-trifluoromethoxyphenyl-3- (1-propionylpiperidin-4-yl) urea attenuates bleomycin-induced pulmonary fibrosis in mice.Inhibition of Chronic Pancreatitis and Murine Pancreatic Intraepithelial Neoplasia by a Dual Inhibitor of c-RAF and Soluble Epoxide Hydrolase in LSL-KrasG¹²D/Pdx-1-Cre Mice.Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress.Soluble Epoxide Hydrolase Inhibition and Epoxyeicosatrienoic Acid Treatment Improve Vascularization of Engineered Skin SubstitutesInhibition of soluble epoxide hydrolase as a novel approach to high dose diazepam induced hypotension.Design and discovery of soluble epoxide hydrolase inhibitors for the treatment of cardiovascular diseases.Ingestion of the epoxide hydrolase inhibitor AUDA modulates immune responses of the mosquito, Culex quinquefasciatus during blood feeding.Characterization of changes in plasma and tissue oxylipin levels in LPS and CLP induced murine sepsis.Effect of a Soluble Epoxide Hydrolase Inhibitor, UC1728, on LPS-Induced Uveitis in the Rabbit.Soluble epoxide hydrolase inhibition Promotes White Matter Integrity and Long-Term Functional Recovery after chronic hypoperfusion in miceIn vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors.Pharmacological inhibition of soluble epoxide hydrolase or genetic deletion reduces diclofenac-induced gastric ulcers.Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization.Screening of soluble epoxide hydrolase inhibitory ingredients from traditional Chinese medicines for anti-inflammatory use.Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain.Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia.
P2860
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P2860
Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Substituted phenyl groups impr ...... e inhibitors in murine models.
@ast
Substituted phenyl groups impr ...... e inhibitors in murine models.
@en
type
label
Substituted phenyl groups impr ...... e inhibitors in murine models.
@ast
Substituted phenyl groups impr ...... e inhibitors in murine models.
@en
prefLabel
Substituted phenyl groups impr ...... e inhibitors in murine models.
@ast
Substituted phenyl groups impr ...... e inhibitors in murine models.
@en
P2093
P2860
P1476
Substituted phenyl groups impr ...... se inhibitors in murine models
@en
P2093
Bruce D Hammock
Christophe Morisseau
Nipavan Chiamvimonvat
Sung Hee Hwang
Tristan E Rose
Yan-Ping Lin
P2860
P304
P356
10.1016/J.EJPS.2012.12.013
P407
P50
P577
2013-01-03T00:00:00Z