EXTL2, a member of the EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner. - Test2 - elhamkhani - TriplyDB

EXTL2, a member of the EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner.

EXTL2, a member of the EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner.

http://www.wikidata.org/entity/Q36725069

about

Crystal structure of the Golgi casein kinase Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans Determinants of Glycosaminoglycan (GAG) Structure Human genetic disorders and knockout mice deficient in glycosaminoglycan The secretory pathway kinases Xylose phosphorylation functions as a molecular switch to regulate proteoglycan biosynthesis Heparan sulfate containing unsubstituted glucosamine residues: biosynthesis and heparanase-inhibitory activity.O-glycosylation of glycine-serine linkers in recombinant Fc-fusion proteins: attachment of glycosaminoglycans and other intermediates with phosphorylation at the xylose sugar subunit.Carriers of loss-of-function mutations in EXT display impaired pancreatic beta-cell reserve due to smaller pancreas volume GlcUAβ1-3Galβ1-3Galβ1-4Xyl(2-O-phosphate) is the preferred substrate for chondroitin N-acetylgalactosaminyltransferase-1.Heparan sulfate proteoglycans undergo differential expression alterations in right sided colorectal cancer, depending on their metastatic character.Reduced Expression of EXTL2, a Member of the Exostosin (EXT) Family of Glycosyltransferases, in Human Embryonic Kidney 293 Cells Results in Longer Heparan Sulfate Chains.Reactivating the extracellular matrix synthesis of sulfated glycosaminoglycans and proteoglycans to improve the human skin aspect and its mechanical properties Polyamines release the let-7b-mediated suppression of initiation codon recognition during the protein synthesis of EXT2.FAM20A mutations associated with enamel renal syndrome.Mechanisms for modulation of neural plasticity and axon regeneration by chondroitin sulphate.Transcriptional Activity of Heparan Sulfate Biosynthetic Machinery is Specifically Impaired in Benign Prostate Hyperplasia and Prostate Cancer.Sulfated glycosaminoglycans: their distinct roles in stem cell biology.Drug-Mediated Regulation of Glycosaminoglycan Biosynthesis.Epigenetic Regulation of the Biosynthesis & Enzymatic Modification of Heparan Sulfate Proteoglycans: Implications for Tumorigenesis and Cancer Biomarkers.Glycosaminoglycan overproduction in the aorta increases aortic calcification in murine chronic kidney disease.Neuroendocrine tumors show altered expression of chondroitin sulfate, glypican 1, glypican 5, and syndecan 2 depending on their differentiation grade.FAM20C functions intracellularly within both ameloblasts and odontoblasts in vivo.3D structural analysis of protein O-mannosyl kinase, POMK, a causative gene product of dystroglycanopathy.Secreted protein kinases?Roles of EXTL2, a member of the EXT family of tumour suppressors, in liver injury and regeneration processes.Chondroitin sulfate-mediated N-cadherin/β-catenin signaling is associated with basal-like breast cancer cell invasion.Computational insights into active site shaping for substrate specificity and reaction regioselectivity in the EXTL2 retaining glycosyltransferase.Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development

P2860

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P2860

EXTL2, a member of the EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner.

http://www.wikidata.org/entity/Q36725069

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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2013年论文

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2013年论文

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name

EXTL2, a member of the EXT fam ...... ylose kinase-dependent manner.

@ast

EXTL2, a member of the EXT fam ...... ylose kinase-dependent manner.

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type

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EXTL2, a member of the EXT fam ...... ylose kinase-dependent manner.

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EXTL2, a member of the EXT fam ...... ylose kinase-dependent manner.

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prefLabel

EXTL2, a member of the EXT fam ...... ylose kinase-dependent manner.

@ast

EXTL2, a member of the EXT fam ...... ylose kinase-dependent manner.

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JBC.M112.416909

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Journal of Biological Chemistry

P1476

EXTL2, a member of the EXT fam ...... ylose kinase-dependent manner.

@en

P2093

Hiroshi Kitagawa

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Kazushi Sugihara

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Kazuyuki Sugahara

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Masahide Asano

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Naoko Shoji

http://www.w3.org/2001/XMLSchema#string

Satomi Nadanaka

http://www.w3.org/2001/XMLSchema#string

Shaobo Zhou

http://www.w3.org/2001/XMLSchema#string

Shoji Kagiyama

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P2860

The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation

The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate

FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan-protein linkage region

Identification and localization of the gene for EXTL, a third member of the multiple exostoses gene family

The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis.

Human glycosaminoglycan glucuronyltransferase I gene and a related processed pseudogene: genomic structure, chromosomal mapping and characterization

Refined physical mapping and genomic structure of the EXTL1 gene

Biosynthesis of decorin and glypican

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells

Functions of cell surface heparan sulfate proteoglycans

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