Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin.
about
Plant-derived anti-inflammatory compounds: hopes and disappointments regarding the translation of preclinical knowledge into clinical progressPlant-derived immunomodulators: an insight on their preclinical evaluation and clinical trialsCell secretion from the adult lamprey supraneural body tissues possesses cytocidal activity against tumor cells.Antivascular and antitumor properties of the tubulin-binding chalcone TUB091Colchicine--Update on mechanisms of action and therapeutic usesA new antiproliferative noscapine analogue: chemical synthesis and biological evaluationDiscovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.Azides derived from colchicine and their use in library synthesis: A practical entry to new bioactive derivatives of an old natural drug.New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies.A-ring dihalogenation increases the cellular activity of combretastatin-templated tetrazolesSynthesis and antiproliferative activities of ottelione a analoguesSyntheses and biological evaluation of ring-C modified colchicine analogsCharacterization of inhibitors of glucocorticoid receptor nuclear translocation: a model of cytoplasmic dynein-mediated cargo transport.New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancerNitroso Diels-Alder (NDA) reaction as an efficient tool for the functionalization of diene-containing natural productsA neurosteroid analogue photolabeling reagent labels the colchicine-binding site on tubulin: a mass spectrometric analysis.Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistanceImmunodetection of retinoblastoma-related protein and its phosphorylated form in interphase and mitotic alfalfa cellsDesign, Synthesis and Cytotoxicity Evaluationof New 1,2-diaryl-4, 5, 6, 7-Tetrahydro-1H-benzo[d] Imidazolesas Tubulin Inhibitors.Convergent synthesis and biological evaluation of 2-amino-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as microtubule targeting agents.Drugs that target dynamic microtubules: a new molecular perspectiveEvaluation of tumor ischemia in response to an indole-based vascular disrupting agent using BLI and (19)F MRI.Design and synthesis of new 2-arylnaphthyridin-4-ones as potent antitumor agents targeting tumorigenic cell lines.Design, synthesis, in vitro, and in vivo anticancer and antiangiogenic activity of novel 3-arylaminobenzofuran derivatives targeting the colchicine site on tubulin.A polymeric colchicinoid prodrug with reduced toxicity and improved efficacy for vascular disruption in cancer therapyDesign and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer.Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitorsDiscovery of a Series of Acridinones as Mechanism-Based Tubulin Assembly Inhibitors with Anticancer Activity.Novel 3-Substituted 7-Phenylpyrrolo[3,2-f]quinolin-9(6H)-ones as Single Entities with Multitarget Antiproliferative ActivityTheoretical and experimental study of polycyclic aromatic compounds as β-tubulin inhibitors.Antiproliferative and cell apoptosis-inducing activities of compounds from Buddleja davidii in Mgc-803 cells.Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitorsSynthesis and biological evaluation of 2-(alkoxycarbonyl)-3-anilinobenzo[b]thiophenes and thieno[2,3-b]pyridines as new potent anticancer agentsNovel tubulin polymerization inhibitors overcome multidrug resistance and reduce melanoma lung metastasisColchicine to decrease NLRP3-activated inflammation and improve obesity-related metabolic dysregulation.Evaluation of biosensor surfaces for the detection of microtubule perturbation.Colchicine Significantly Reduces Incident Cancer in Gout Male Patients: A 12-Year Cohort Study.Microtubule dynamics as a target in oncology.Structure-activity relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride and its analogues as antitumor agents.
P2860
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P2860
Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Anti-mitotic activity of colch ...... its interaction with tubulin.
@ast
Anti-mitotic activity of colch ...... its interaction with tubulin.
@en
type
label
Anti-mitotic activity of colch ...... its interaction with tubulin.
@ast
Anti-mitotic activity of colch ...... its interaction with tubulin.
@en
prefLabel
Anti-mitotic activity of colch ...... its interaction with tubulin.
@ast
Anti-mitotic activity of colch ...... its interaction with tubulin.
@en
P2093
P356
P1476
Anti-mitotic activity of colch ...... its interaction with tubulin.
@en
P2093
Bhabatarak Bhattacharyya
Dulal Panda
Mithu Banerjee
Suvroma Gupta
P304
P356
10.1002/MED.20097
P577
2008-01-01T00:00:00Z