HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases
about
Retroviral DNA IntegrationSelectivity for strand-transfer over 3'-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site.Drug resistant integrase mutants cause aberrant HIV integrations.Retroviral integrase protein and intasome nucleoprotein complex structures.Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors.Probing Resistance Mutations in Retroviral Integrases by Direct Measurement of Dolutegravir Fluorescence.Developing and evaluating inhibitors against the RNase H active site of HIV-1 RT.Efficacies of Cabotegravir and Bictegravir against drug-resistant HIV-1 integrase mutants.
P2860
Q28596842-EB11D849-9927-431F-82C0-18E95476AC85Q37211035-FB4F2180-31D5-4125-B385-A1E6A656B4E8Q37294690-FE0154DF-927A-41C5-A1DF-893722479FBFQ39176798-FCEFBF4C-E11E-44E8-86AB-1D489373E66FQ41722020-53E07775-B7D0-453B-8094-5F36E8C529F7Q42630471-102EF948-D10E-4315-82DB-1E7580919565Q52593232-9FEF1C5D-E5C2-42D2-B5E7-86F2DF60EAAAQ54209728-9FAA85A5-F924-479F-B782-83F1530417D5
P2860
HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
HIV-1 Integrase Strand Transfe ...... ug Resistant Mutant Integrases
@ast
HIV-1 Integrase Strand Transfe ...... ug Resistant Mutant Integrases
@en
type
label
HIV-1 Integrase Strand Transfe ...... ug Resistant Mutant Integrases
@ast
HIV-1 Integrase Strand Transfe ...... ug Resistant Mutant Integrases
@en
prefLabel
HIV-1 Integrase Strand Transfe ...... ug Resistant Mutant Integrases
@ast
HIV-1 Integrase Strand Transfe ...... ug Resistant Mutant Integrases
@en
P2093
P2860
P50
P1433
P1476
HIV-1 Integrase Strand Transfe ...... ug Resistant Mutant Integrases
@en
P2093
Christophe Marchand
Daniel P Maskell
Katherine Fesen
Mathieu Metifiot
Stephen H Hughes
Steven J Smith
Terrence R Burke
Yves Pommier
P2860
P304
P356
10.1021/ACSCHEMBIO.5B00948
P577
2016-02-05T00:00:00Z