Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts. - Test2 - elhamkhani - TriplyDB

Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts.

Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts.

http://www.wikidata.org/entity/Q36826814

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Hepatoprotective and Anti-fibrotic Agents: It's Time to Take the Next Step CCN: core regulatory proteins in the microenvironment that affect the metastasis of hepatocellular carcinoma?Extracellular matrix and liver disease The wound healing, chronic fibrosis, and cancer progression triad Lysophosphatidic acid alters the expression profiles of angiogenic factors, cytokines, and chemokines in mouse liver sinusoidal endothelial cells Loss of pericyte smoothened activity in mice with genetic deficiency of leptin.Interplay between CCN1 and Wnt5a in endothelial cells and pericytes determines the angiogenic outcome in a model of ischemic retinopathy.Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection.An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA Mouse models of liver fibrosis mimic human liver fibrosis of different etiologies.Simvastatin suppresses breast cancer cell proliferation induced by senescent cells Estrogen-induced CCN1 is critical for establishment of endometriosis-like lesions in mice Hypoxia-induced deoxycytidine kinase contributes to epithelial proliferation in pulmonary fibrosis.Oxidant exposure induces cysteine-rich protein 61 (CCN1) via c-Jun/AP-1 to reduce collagen expression in human dermal fibroblasts Effects of CD14 and TLR4 on LPS-mediated normal human skin fibroblast proliferation.Association of CD14 and TLR4 with LPS-stimulated human normal skin fibroblasts in immunophenotype changes and secretion of TGF-β1 and IFN-γ.CCN1 induces hepatic ductular reaction through integrin αvβ₅-mediated activation of NF-κB.Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin.G Protein-Coupled Receptor and RhoA-Stimulated Transcriptional Responses: Links to Inflammation, Differentiation, and Cell Proliferation.The matricellular protein CCN1 mediates neutrophil efferocytosis in cutaneous wound healing The matricellular protein CCN1 controls retinal angiogenesis by targeting VEGF, Src homology 2 domain phosphatase-1 and Notch signaling.The matricellular protein CCN1 promotes mucosal healing in murine colitis through IL-6.Soluble Egg Antigens of Schistosoma japonicum Induce Senescence of Activated Hepatic Stellate Cells by Activation of the FoxO3a/SKP2/P27 Pathway.Single and Compound Knock-outs of MicroRNA (miRNA)-155 and Its Angiogenic Gene Target CCN1 in Mice Alter Vascular and Neovascular Growth in the Retina via Resident Microglia Age-dependent development of liver fibrosis in Glmp (gt/gt) mice.CCN1 (CYR61) and CCN3 (NOV) signaling drives human trophoblast cells into senescence and stimulates migration properties The matricellular protein CCN1 enhances TGF-β1/SMAD3-dependent profibrotic signaling in fibroblasts and contributes to fibrogenic responses to lung injury.Transforming growth factor-β-sphingosine kinase 1/S1P signaling upregulates microRNA-21 to promote fibrosis in renal tubular epithelial cells Soluble egg antigens of Schistosoma japonicum induce senescence in activated hepatic stellate cells by activation of the STAT3/p53/p21 pathway Members of the Cyr61/CTGF/NOV Protein Family: Emerging Players in Hepatic Progenitor Cell Activation and Intrahepatic Cholangiocarcinoma.Cysteine-rich protein 61 (CCN1) and connective tissue growth factor (CCN2) at the crosshairs of ocular neovascular and fibrovascular disease therapy.Molecular control of vascular development by the matricellular proteins CCN1 (Cyr61) and CCN2 (CTGF).Assembly of human organs from stem cells to study liver disease.Hepatic stellate cells and extracellular matrix in hepatocellular carcinoma: more complicated than ever.Cellular senescence and its effector programs.Physiological and pathological consequences of cellular senescence.Cellular and molecular actions of CCN2/CTGF and its role under physiological and pathological conditions.Early to Phase II drugs currently under investigation for the treatment of liver fibrosis.Cellular senescence: from growth arrest to immunogenic conversion.NADPH Oxidases in Chronic Liver Diseases

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P2860

Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts.

http://www.wikidata.org/entity/Q36826814

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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2013年论文

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2013年论文

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name

Matricellular protein CCN1 pro ...... nce in hepatic myofibroblasts.

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type

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Matricellular protein CCN1 pro ...... nce in hepatic myofibroblasts.

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Matricellular protein CCN1 pro ...... nce in hepatic myofibroblasts.

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Molecular and Cellular Biology

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Matricellular protein CCN1 pro ...... ence in hepatic myofibroblasts

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Chih-Chiun Chen

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Ki-Hyun Kim

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Ricardo I Monzon

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P2860

Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo

Nox1-dependent reactive oxygen generation is regulated by Rac1

CYR61 (CCN1) is essential for placental development and vascular integrity

Cellular senescence controls fibrosis in wound healing

Senescence of activated stellate cells limits liver fibrosis

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

Vascular endothelial growth factor (VEGF)-induced up-regulation of CCN1 in osteoblasts mediates proangiogenic activities in endothelial cells and promotes fracture healing

Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: lessons from transgenic animals

The matricellular protein CCN1 is essential for cardiac development

Cytotoxicity of TNFalpha is regulated by integrin-mediated matrix signaling

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2078-2090

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scholarly article

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10.1128/MCB.00049-13

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10

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33

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2013-03-18T00:00:00Z

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23508104

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3647960

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