Proteome-wide profiling of isoniazid targets in Mycobacterium tuberculosis.
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Strategies for potentiation of ethionamide and folate antagonists against Mycobacterium tuberculosisNew Insight into the Mechanism of Action of and Resistance to Isoniazid: Interaction of Mycobacterium tuberculosis enoyl-ACP Reductase with INH-NADPTriazaspirodimethoxybenzoyls as Selective Inhibitors of Mycobacterial Lipoamide Dehydrogenase,Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzymeA structural characterization of the isoniazidMycobacterium tuberculosisdrug target, Rv2971, in its unliganded formThe essential mycobacterial genes, fabG1 and fabG4, encode 3-oxoacyl-thioester reductases that are functional in yeast mitochondrial fatty acid synthase type 2TB Mobile: a mobile app for anti-tuberculosis molecules with known targetsInsights into the pharmacokinetic properties of antitubercular drugs.Inhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: structure-activity relationships of the nucleobase domain of 5'-O-[N-(salicyl)sulfamoyl]adenosine.Slow onset inhibition of bacterial beta-ketoacyl-acyl carrier protein synthases by thiolactomycin.Mycobacterium tuberculosis nucleoid-associated DNA-binding protein H-NS binds with high-affinity to the Holliday junction and inhibits strand exchange promoted by RecA protein.Protein-protein interaction networks suggest different targets have different propensities for triggering drug resistance.Metabolomics of urine for the assessment of microvesicular lipid accumulation in the liver following isoniazid exposureBioactivation of antituberculosis thioamide and thiourea prodrugs by bacterial and mammalian flavin monooxygenases.The path of anti-tuberculosis drugs: from blood to lesions to mycobacterial cells.Using a Label Free Quantitative Proteomics Approach to Identify Changes in Protein Abundance in Multidrug-Resistant Mycobacterium tuberculosis.Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria.Antibiotic resistance in Mycobacterium tuberculosis: peroxidase intermediate bypass causes poor isoniazid activation by the S315G mutant of M. tuberculosis catalase-peroxidase (KatG)Characterizing the pocketome of Mycobacterium tuberculosis and application in rationalizing polypharmacological target selection.Proteomic signatures in antibiotic research.Targeting InhA, the FASII enoyl-ACP reductase: SAR studies on novel inhibitor scaffolds.Navigating tuberculosis drug discovery with target-based screening.Advances In Mycobacterium Tuberculosis Therapeutics Discovery Utlizing Structural Biology.Drug Resistance Mechanisms in Mycobacterium tuberculosis.Mycobacterium tuberculosis dihydrofolate reductase is not a target relevant to the antitubercular activity of isoniazid.Affinity-based profiling of dehydrogenase subproteomes.Modeling metabolic adjustment in Mycobacterium tuberculosis upon treatment with isoniazidIsoniazid metal complex reactivity and insights for a novel anti-tuberculosis drug design.Biochemical Characterization of Isoniazid-resistant Can the Analysis of Clonal Strains Reveal Novel Targetable Pathways?2-D Gel-Based Proteomic Approaches to Antibiotic Drug Discovery
P2860
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P2860
Proteome-wide profiling of isoniazid targets in Mycobacterium tuberculosis.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Proteome-wide profiling of isoniazid targets in Mycobacterium tuberculosis.
@en
type
label
Proteome-wide profiling of isoniazid targets in Mycobacterium tuberculosis.
@en
prefLabel
Proteome-wide profiling of isoniazid targets in Mycobacterium tuberculosis.
@en
P2093
P2860
P356
P1433
P1476
Proteome-wide profiling of isoniazid targets in Mycobacterium tuberculosis.
@en
P2093
Argyrides Argyrou
John S Blanchard
Lianji Jin
Linda Siconilfi-Baez
Ruth H Angeletti
P2860
P304
13947-13953
P356
10.1021/BI061874M
P407
P577
2006-11-01T00:00:00Z