Strong cortical and spinal cord transduction after AAV7 and AAV9 delivery into the cerebrospinal fluid of nonhuman primates. - Test2 - elhamkhani - TriplyDB

Strong cortical and spinal cord transduction after AAV7 and AAV9 delivery into the cerebrospinal fluid of nonhuman primates.

Strong cortical and spinal cord transduction after AAV7 and AAV9 delivery into the cerebrospinal fluid of nonhuman primates.

http://www.wikidata.org/entity/Q36848703

about

Biology of adeno-associated viral vectors in the central nervous system Adeno Associated Viral Vector Delivered RNAi for Gene Therapy of SOD1 Amyotrophic Lateral Sclerosis Clinical development of gene therapy: results and lessons from recent successes Adeno-associated virus-delivered artificial microRNA extends survival and delays paralysis in an amyotrophic lateral sclerosis mouse model.In vivo dynamics of AAV-mediated gene delivery to sensory neurons of the trigeminal ganglia Biodistribution of adeno-associated virus serotype 9 (AAV9) vector after intrathecal and intravenous delivery in mouse Catalytic immunoglobulin gene delivery in a mouse model of Alzheimer's disease: prophylactic and therapeutic applications.In vivo disruption of latent HSV by designer endonuclease therapy Intracisternal delivery of NFκB-inducible scAAV2/9 reveals locoregional neuroinflammation induced by systemic kainic acid treatment.Improving single injection CSF delivery of AAV9-mediated gene therapy for SMA: a dose-response study in mice and nonhuman primates.Gene therapy for the nervous system: challenges and new strategies.Widespread gene transfer in the central nervous system of cynomolgus macaques following delivery of AAV9 into the cisterna magna.Controlling AAV Tropism in the Nervous System with Natural and Engineered Capsids.Clinical applications involving CNS gene transfer.Strategies to circumvent humoral immunity to adeno-associated viral vectors.AAV9-mediated central nervous system-targeted gene delivery via cisterna magna route in mice.Cerebellomedullary Cistern Delivery for AAV-Based Gene Therapy: A Technical Note for Nonhuman Primates A Comprehensive Map of CNS Transduction by Eight Recombinant Adeno-associated Virus Serotypes Upon Cerebrospinal Fluid Administration in Pigs.Widespread AAV1- and AAV2-mediated transgene expression in the nonhuman primate brain: implications for Huntington's disease.Intrathecal administration of AAV/GALC vectors in 10-11-day-old twitcher mice improves survival and is enhanced by bone marrow transplant Current Challenges and Future Directions in Recombinant AAV-Mediated Gene Therapy of Duchenne Muscular Dystrophy.Better Targeting, Better Efficiency for Wide-Scale Neuronal Transduction with the Synapsin Promoter and AAV-PHP.B.AAV9-mediated expression of a non-self protein in nonhuman primate central nervous system triggers widespread neuroinflammation driven by antigen-presenting cell transduction.Novel Vector Design and Hexosaminidase Variant Enabling Self-Complementary Adeno-Associated Virus for the Treatment of Tay-Sachs Disease.Distribution of nanoparticles throughout the cerebral cortex of rodents and non-human primates: Implications for gene and drug therapy.Optical stimulation for restoration of motor function after spinal cord injury.Gene therapy and peripheral nerve repair: a perspective.Convection-enhanced delivery in glioblastoma: a review of preclinical and clinical studies.MR-guided parenchymal delivery of adeno-associated viral vector serotype 5 in non-human primate brain.Adenoassociated virus serotype 9-mediated gene therapy for x-linked adrenoleukodystrophy.Antibody neutralization poses a barrier to intravitreal adeno-associated viral vector gene delivery to non-human primates Advances in optogenetic and chemogenetic methods to study brain circuits in non-human primates.Intracisternal delivery of AAV9 results in oligodendrocyte and motor neuron transduction in the whole central nervous system of cats.Efficient CNS targeting in adult mice by intrathecal infusion of single-stranded AAV9-GFP for gene therapy of neurological disorders.Gene therapy for a mouse model of glucose transporter-1 deficiency syndrome.Intraneural convection enhanced delivery of AAVrh20 for targeting primary sensory neurons.Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors.High cerebrospinal fluid levels of interleukin-10 attained by AAV in dogs.Long-term neurologic and cardiac correction by intrathecal gene therapy in Pompe disease.Slow intrathecal injection of rAAVrh10 enhances its transduction of spinal cord and therapeutic efficacy in a mutant SOD1 model of ALS.

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P2860

Strong cortical and spinal cord transduction after AAV7 and AAV9 delivery into the cerebrospinal fluid of nonhuman primates.

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Adrian P Kells

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Ernesto A Salegio

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John Forsayeth

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John R Bringas

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P2860

A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10

Cerebral infusion of AAV9 vector-encoding non-self proteins can elicit cell-mediated immune responses.

Over the barrier and through the blood: to CNS delivery we go.

Systemic gene delivery in large species for targeting spinal cord, brain, and peripheral tissues for pediatric disorders

Adeno-associated virus vectors can be efficiently produced without helper virus.

Gene therapy using adeno-associated virus vectors

Preclinical differences of intravascular AAV9 delivery to neurons and glia: a comparative study of adult mice and nonhuman primates

Recombinant adeno-associated virus: formulation challenges and strategies for a gene therapy vector.

Adeno-associated virus antibody profiles in newborns, children, and adolescents

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5

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cerebrospinal fluid

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