Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: review of sphingosine kinase inhibitors.
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Sphingosine-1-Phosphate Receptor-2 Antagonists: Therapeutic Potential and Potential RisksThe role of sphingosine-1-phosphate in endothelial barrier functionTamoxifen regulation of sphingolipid metabolism--Therapeutic implicationsTransforming Sphingosine Kinase 1 Inhibitors into Dual and Sphingosine Kinase 2 Selective Inhibitors: Design, Synthesis, and in Vivo Activity.Structural Requirements and Docking Analysis of Amidine-Based Sphingosine Kinase 1 Inhibitors Containing Oxadiazoles.Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia--Impact on enzyme activity and response to cytotoxics.The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines.Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3Sphingosine kinase activity is not required for tumor cell viabilityThe Concise Guide to PHARMACOLOGY 2013/14: enzymes.Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget.Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond.Sphingosine kinase 1 (Sphk1) negatively regulates platelet activation and thrombus formationSphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection.Switching the sphingolipid rheostat in the treatment of diabetes and cancer comorbidity from a problem to an advantage.A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties.Maternal and Zygotic Sphingosine Kinase 2 Are Indispensable for Cardiac Development in Zebrafish.A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma.Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer.Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in Mice.Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo.Sphingosine Kinase 1 Protects Hepatocytes from Lipotoxicity via Down-regulation of IRE1α Protein ExpressionThe Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo.Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2.Implication of sphingosin-1-phosphate in cardiovascular regulation.Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants.Bioactive lysophospholipids: role in regulation of aqueous humor outflow and intraocular pressure in the context of pathobiology and therapy of glaucoma.Influenza viral manipulation of sphingolipid metabolism and signaling to modulate host defense system.Sphingosine-1-phosphate metabolism: A structural perspective.Lmo2 (LIM-Domain-Only 2) Modulates Sphk1 (Sphingosine Kinase) and Promotes Endothelial Cell Migration.Sphingosine kinase 2 is a chikungunya virus host factor co-localized with the viral replication complex.Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis.Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism.Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology.Sphingosine kinase 2-deficiency mediated changes in spinal pain processing.Inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II.Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cells.Sphingosine kinase 1 regulates measles virus replication.Sphingosine kinase: a closer look at last.Sphingosine kinase 1 mediates diabetic renal fibrosis via NF-κB signaling pathway: involvement of CK2α.
P2860
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P2860
Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: review of sphingosine kinase inhibitors.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Targeting the sphingosine kina ...... sphingosine kinase inhibitors.
@en
type
label
Targeting the sphingosine kina ...... sphingosine kinase inhibitors.
@en
prefLabel
Targeting the sphingosine kina ...... sphingosine kinase inhibitors.
@en
P2860
P1476
Targeting the sphingosine kina ...... sphingosine kinase inhibitors.
@en
P2093
K Alexa Orr Gandy
Lina M Obeid
P2860
P304
P356
10.1016/J.BBALIP.2012.07.002
P407
P577
2012-07-16T00:00:00Z