Inhibition of Heat Shock Protein 90 Prevents HIV Rebound
about
Activation of HIV-1 expression in latently infected CD4+ T cells by the small molecule PKC412.HSP90: a promising broad-spectrum antiviral drug target.Heat Shock Protein 90 Facilitates Latent HIV Reactivation through Maintaining the Function of Positive Transcriptional Elongation Factor b (p-TEFb) under Proteasome Inhibition.Quiescence promotes latent HIV infection and resistance to reactivation from latency with histone deacetylase inhibitors.Class 1-selective histone deacetylase inhibitors enhance HIV latency reversal while preserving the activity of HDAC isoforms necessary for maximal HIV gene expression.Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation.
P2860
Inhibition of Heat Shock Protein 90 Prevents HIV Rebound
description
2016 nî lūn-bûn
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2016年の論文
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2016年論文
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2016年論文
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2016年論文
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2016年論文
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2016年論文
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2016年论文
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2016年论文
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2016年论文
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name
Inhibition of Heat Shock Protein 90 Prevents HIV Rebound
@en
type
label
Inhibition of Heat Shock Protein 90 Prevents HIV Rebound
@en
prefLabel
Inhibition of Heat Shock Protein 90 Prevents HIV Rebound
@en
P2860
P356
P1476
Inhibition of Heat Shock Protein 90 Prevents HIV Rebound
@en
P2093
Cheryl A Stoddart
Pheroze Joshi
P2860
P304
10332-10346
P356
10.1074/JBC.M116.717538
P407
P577
2016-03-08T00:00:00Z