The posttranslational modification cascade to the thiopeptide berninamycin generates linear forms and altered macrocyclic scaffolds
about
Thiopeptide antibiotics: retrospective and recent advancesA systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics.Heterologous expression of the thiopeptide antibiotic GE2270 from Planobispora rosea ATCC 53733 in Streptomyces coelicolor requires deletion of ribosomal genes from the expression construct.The genomic landscape of ribosomal peptides containing thiazole and oxazole heterocycles.Structure-based Mechanistic Insights into Terminal Amide Synthase in Nosiheptide-Represented Thiopeptides BiosynthesisAntagonism between Staphylococcus epidermidis and Propionibacterium acnes and its genomic basis.Functional roles in S-adenosyl-L-methionine binding and catalysis for active site residues of the thiostrepton resistance methyltransferaseElucidating and engineering thiopeptide biosynthesis.New Insights into the Biosynthetic Logic of Ribosomally Synthesized and Post-translationally Modified Peptide Natural Products.Saturation mutagenesis of TsrA Ala4 unveils a highly mutable residue of thiostrepton A.An α/β-hydrolase fold protein in the biosynthesis of thiostrepton exhibits a dual activity for endopeptidyl hydrolysis and epoxide ring opening/macrocyclization.Cloning and Heterologous Expression of a Large-sized Natural Product Biosynthetic Gene Cluster in Streptomyces SpeciesYcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function.Post-translational modifications involved in the biosynthesis of thiopeptide antibiotics.Reconstitution and Minimization of a Micrococcin Biosynthetic Pathway in Bacillus subtilis.Unique post-translational oxime formation in the biosynthesis of the azolemycin complex of novel ribosomal peptides from Streptomyces sp. FXJ1.264Antibiotics and specialized metabolites from the human microbiota.Mutagenesis of NosM Leader Peptide Reveals Important Elements in Nosiheptide BiosynthesisInsight into bicyclic thiopeptide biosynthesis benefited from development of a uniform approach for molecular engineering and production improvementHeterologous Production of Microbial Ribosomally Synthesized and Post-translationally Modified Peptides
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P2860
The posttranslational modification cascade to the thiopeptide berninamycin generates linear forms and altered macrocyclic scaffolds
description
2013 nî lūn-bûn
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2013年の論文
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2013年論文
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2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
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2013年论文
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name
The posttranslational modifica ...... altered macrocyclic scaffolds
@en
type
label
The posttranslational modifica ...... altered macrocyclic scaffolds
@en
prefLabel
The posttranslational modifica ...... altered macrocyclic scaffolds
@en
P2093
P2860
P356
P1476
The posttranslational modifica ...... altered macrocyclic scaffolds
@en
P2093
Christopher T Walsh
J Graham Ruby
Peter Skewes-Cox
Steven J Malcolmson
Travis S Young
P2860
P304
P356
10.1073/PNAS.1307111110
P407
P577
2013-05-06T00:00:00Z