Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function.
about
Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling.Human pluripotent stem cell differentiation to functional pancreatic cells for diabetes therapies: Innovations, challenges and future directions.Human islets contain four distinct subtypes of β cellsSingle-cell transcriptomes identify human islet cell signatures and reveal cell-type-specific expression changes in type 2 diabetes.Characterization of OATP1B3 and OATP2B1 transporter expression in the islet of the adult human pancreas.Effects of ageing and senescence on pancreatic β-cell function.Role of the gut microbiota in host appetite control: bacterial growth to animal feeding behaviour.Epigenetic control of β-cell function and failure.Is a β cell a β cell?Genomics of Islet (Dys)function and Type 2 Diabetes.All mixed up: defining roles for β-cell subtypes in mature islets.Systematic single-cell analysis provides new insights into heterogeneity and plasticity of the pancreas.Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis.Epigenetics in formation, function, and failure of the endocrine pancreas.Alpha TC1 and Beta-TC-6 genomic profiling uncovers both shared and distinct transcriptional regulatory features with their primary islet counterparts.Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas.Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns.Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling.Replication confers β cell immaturity.Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets.Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx.Menin and PRMT5 suppress GLP1 receptor transcript and PKA-mediated phosphorylation of FOXO1 and CREB.Identification and functional analysis of glycemic trait loci in the China Health and Nutrition Survey.Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish.miR-7 Modulates hESC Differentiation into Insulin-Producing Beta-like Cells and Contributes to Cell MaturationThe Future of Islet Transplantation Is NowDiscovering human diabetes-risk gene function with genetics and physiological assays
P2860
Q30313776-FD0DB1F3-6EFA-4EC3-95A4-E9987E49E218Q33864580-1F2F92F6-04BD-4EEF-B111-9C52247280ECQ37089019-4E67E760-6FBB-4729-9D79-7263159D86EBQ37619113-79FD3A31-3626-4C52-9A56-9FC0C24A139EQ38685293-65B58446-9EA0-4090-8B44-2FFB89E11626Q38951152-98AB9E34-F1F7-486C-B878-0C07C4AEE293Q38951451-EFBF38E3-C6D7-42A5-AD18-675FBFAB9909Q39029575-7E661264-46FC-422C-9FD2-1BE907F56368Q39093694-3DCE5EA5-F9C5-4F8C-AED0-FEE22E997209Q39155009-8747077B-9624-4918-A7B0-B64497222DE2Q39167044-F66865C6-BB8D-4E75-9661-B55AAA3B42D9Q41689669-1C50D2A6-55E1-4105-840C-519BD0F61407Q41689680-2EAA8A53-44DE-4D39-AF64-15B587401415Q41689688-EC3FF6EC-CDE9-4B4F-9AD8-D90755D13BD4Q41696872-88446B6D-9697-4082-AFF0-63AAD9EB0D25Q42282703-EDFFE218-D859-431C-A6D2-D7BA3E125D4AQ42777917-65B56609-CE4C-40D9-A267-0E961B74094EQ44899742-91A8BC18-A78E-4347-BA10-DCCC6B2861CFQ48113320-4833579E-FFAE-4804-B74B-D4BA02178D41Q48334203-610DF6C6-8BDC-46C0-AB48-B20C1E89C05CQ50455092-D48ADCA1-0DBD-45C8-8CEF-375C84D0071FQ51107548-2E8A2EC2-3E1C-478D-AA0B-E609089B98CCQ52690721-BC7970A7-B6D1-4B4B-A36F-74BF8276FC46Q52721177-0F7F4318-FB72-4670-96F0-49F5427D4FE8Q57159709-00B32111-B401-4599-83C0-AF8F17EDB94FQ57176134-E570799A-A0BC-4DCE-AAE5-BA9A28C57AC5Q58705850-6502501D-6875-4521-81A6-036C23749E10
P2860
Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Age-Dependent Pancreatic Gene ...... verning Human β Cell Function.
@en
type
label
Age-Dependent Pancreatic Gene ...... verning Human β Cell Function.
@en
prefLabel
Age-Dependent Pancreatic Gene ...... verning Human β Cell Function.
@en
P2093
P2860
P1433
P1476
Age-Dependent Pancreatic Gene ...... verning Human β Cell Function.
@en
P2093
Alvin C Powers
Chunhua Dai
Eduardo A Torre
H Efsun Arda
Heshan Peiris
Howard Y Chang
Jennifer Tsai
P2860
P304
P356
10.1016/J.CMET.2016.04.002
P577
2016-04-27T00:00:00Z