CLP1 links tRNA metabolism to progressive motor-neuron loss.
about
Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system functionCLP1 founder mutation links tRNA splicing and maturation to cerebellar development and neurodegenerationMechanisms of FUS mutations in familial amyotrophic lateral sclerosisMultiple Layers of Stress-Induced Regulation in tRNA BiologySmall Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human DiseasesBeyond the Ribosome: Extra-translational Functions of tRNA FragmentstRNA-Derived Fragments (tRFs): Emerging New Roles for an Ancient RNA in the Regulation of Gene ExpressionNeuroblastoma: oncogenic mechanisms and therapeutic exploitation of necroptosisRegulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genestRNA fragments in human health and diseaseModify or die?--RNA modification defects in metazoansSurveillance and cleavage of eukaryotic tRNAsMultiplicity of 5' cap structures present on short RNAsPrecise mapping and dynamics of tRNA-derived fragments (tRFs) in the development of Triops cancriformis (tadpole shrimp)tRF2Cancer: A web server to detect tRNA-derived small RNA fragments (tRFs) and their expression in multiple cancers.Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing.Noncoding RNA: Current Deep Sequencing Data Analysis Approaches and Challenges.MINTmap: fast and exhaustive profiling of nuclear and mitochondrial tRNA fragments from short RNA-seq data.Mutations in VRK1 associated with complex motor and sensory axonal neuropathy plus microcephaly.Transfer RNA and human diseasetRNAs as regulators of biological processesSmall RNA fragments derived from multiple RNA classes - the missing element of multi-omics characteristics of the hepatitis C virus cell culture modelAberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.Slicing tRNAs to boost functional ncRNA diversity.Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damagetRNA-Derived Short Non-coding RNA as Interacting Partners of Argonaute ProteinsSynaptic vesicles contain small ribonucleic acids (sRNAs) including transfer RNA fragments (trfRNA) and microRNAs (miRNA).The RtcB RNA ligase is an essential component of the metazoan unfolded protein response.Cutting, dicing, healing and sealing: the molecular surgery of tRNAGlobal analysis of RNA cleavage by 5'-hydroxyl RNA sequencing.ARM-seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragmentsRNA ligation in neurons by RtcB inhibits axon regeneration.Identification of Mitochondrial Genome-Encoded Small RNAs Related to Egg Deterioration Caused by Postovulatory Aging in Rainbow Trout.tRNA processing defects induce replication stress and Chk2-dependent disruption of piRNA transcription.GtRNAdb 2.0: an expanded database of transfer RNA genes identified in complete and draft genomesThe Many Virtues of tRNA-derived Stress-induced RNAs (tiRNAs): Discovering Novel Mechanisms of Stress Response and Effect on Human HealthRNA Polymerase III Advances: Structural and tRNA Functional Views.Cerebrospinal fluid of newly diagnosed amyotrophic lateral sclerosis patients exhibits abnormal levels of selenium species including elevated selenite.An investigation into the role of ATP in the mammalian pre-mRNA 3' cleavage reactionTargeted deletion of the gene encoding the La autoantigen (Sjögren's syndrome antigen B) in B cells or the frontal brain causes extensive tissue loss.
P2860
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P2860
CLP1 links tRNA metabolism to progressive motor-neuron loss.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
CLP1 links tRNA metabolism to progressive motor-neuron loss.
@en
type
label
CLP1 links tRNA metabolism to progressive motor-neuron loss.
@en
prefLabel
CLP1 links tRNA metabolism to progressive motor-neuron loss.
@en
P2093
P2860
P50
P356
P1433
P1476
CLP1 links tRNA metabolism to progressive motor-neuron loss.
@en
P2093
Akihiko Yoshimura
Avraham Yaron
Brian J Wainger
Christian Bernreuther
Clifford J Woolf
Fuminori Sato
Hiromitsu Mimata
Javier Martinez
P2860
P2888
P304
P356
10.1038/NATURE11923
P407
P577
2013-03-10T00:00:00Z