The loss of the BH3-only Bcl-2 family member Bid delays T-cell leukemogenesis in Atm-/- mice
about
Genomic quantitative real-time PCR proves residual disease positivity in more than 30% samples with negative mRNA-based qRT-PCR in Chronic Myeloid LeukemiaLimited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death.Non-apoptotic functions of BCL-2 family proteins.The BH3-only protein BID impairs the p38-mediated stress response and promotes hepatocarcinogenesis during chronic liver injury in mice.JNK1/2 regulate Bid by direct phosphorylation at Thr59 in response to ALDH1L1.Phosphorylation of the proapoptotic BH3-only protein bid primes mitochondria for apoptosis during mitotic arrest.Genetic background and tumour susceptibility in mouse models.Loss of BIM augments resistance of ATM-deficient thymocytes to DNA damage-induced apoptosis but does not accelerate lymphoma development.
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The loss of the BH3-only Bcl-2 family member Bid delays T-cell leukemogenesis in Atm-/- mice
description
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name
The loss of the BH3-only Bcl-2 ...... leukemogenesis in Atm-/- mice
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type
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The loss of the BH3-only Bcl-2 ...... leukemogenesis in Atm-/- mice
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prefLabel
The loss of the BH3-only Bcl-2 ...... leukemogenesis in Atm-/- mice
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The loss of the BH3-only Bcl-2 ...... leukemogenesis in Atm-/- mice
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10.1038/CDD.2013.16
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2013-03-08T00:00:00Z