Conditional deletion of Atoh1 reveals distinct critical periods for survival and function of hair cells in the organ of Corti.
about
Segregating neural and mechanosensory fates in the developing ear: patterning, signaling, and transcriptional control.Sensory hair cell development and regeneration: similarities and differencesWhere hearing starts: the development of the mammalian cochleaTranscription Factors Expressed in Mouse Cochlear Inner and Outer Hair CellsSingle-cell RNA-Seq resolves cellular complexity in sensory organs from the neonatal inner ear.Neurog1 can partially substitute for Atoh1 function in hair cell differentiation and maintenance during organ of Corti developmentInner ear development: building a spiral ganglion and an organ of Corti out of unspecified ectodermCharacterization of the transcriptome of nascent hair cells and identification of direct targets of the Atoh1 transcription factorSupporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice.Atoh1 as a Coordinator of Sensory Hair Cell Development and Regeneration in the Cochlea.Organ of Corti and Stria Vascularis: Is there an Interdependence for Survival?Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disordersThe Role of Atonal Factors in Mechanosensory Cell Specification and FunctionChanges in the regulation of the Notch signaling pathway are temporally correlated with regenerative failure in the mouse cochleaSensational placodes: neurogenesis in the otic and olfactory systems.mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseasesβ-Catenin is required for hair-cell differentiation in the cochlea.Large basolateral processes on type II hair cells are novel processing units in mammalian vestibular organs.Hey1 and Hey2 control the spatial and temporal pattern of mammalian auditory hair cell differentiation downstream of Hedgehog signalingOpportunities and limits of the one gene approach: the ability of Atoh1 to differentiate and maintain hair cells depends on the molecular contextMechanisms of otoconia and otolith developmentCMV-induced embryonic mouse organ of corti dysplasia: Network architecture of dysfunctional lateral inhibition.Overview of genetic tools and techniques to study Notch signaling in mice.Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter.Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates.Can the 'neuron theory' be complemented by a universal mechanism for generic neuronal differentiation.Atoh1 gene therapy in the cochlea for hair cell regeneration.New treatment options for hearing loss.Insights into inner ear-specific gene regulation: Epigenetics and non-coding RNAs in inner ear development and regeneration.Cochlear hair cell regeneration after noise-induced hearing loss: Does regeneration follow development?Concise Review: Regeneration in Mammalian Cochlea Hair Cells: Help from Supporting Cells Transdifferentiation.Quantitative Analysis of Supporting Cell Subtype Labeling Among CreER Lines in the Neonatal Mouse Cochlea.Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.LIN-32/Atonal Controls Oxygen Sensing Neuron Development in Caenorhabditis elegans.Molecular cloning and functional characterisation of chicken Atonal homologue 1: a comparison with human Atoh1.Green Tea Polyphenols Protects Cochlear Hair Cells from Ototoxicity by Inhibiting Notch Signalling.Using Drosophila to study mechanisms of hereditary hearing loss.Gene Therapy in Mouse Models of Deafness and Balance Dysfunction
P2860
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P2860
Conditional deletion of Atoh1 reveals distinct critical periods for survival and function of hair cells in the organ of Corti.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Conditional deletion of Atoh1 ...... r cells in the organ of Corti.
@en
type
label
Conditional deletion of Atoh1 ...... r cells in the organ of Corti.
@en
prefLabel
Conditional deletion of Atoh1 ...... r cells in the organ of Corti.
@en
P2093
P2860
P1476
Conditional deletion of Atoh1 ...... ir cells in the organ of Corti
@en
P2093
Fred A Pereira
Hongyuan Zhang
Michelle L Seymour
Tiantian Cai
P2860
P304
10110-10122
P356
10.1523/JNEUROSCI.5606-12.2013
P407
P577
2013-06-01T00:00:00Z