Thermodynamic basis for promiscuity and selectivity in protein-protein interactions: PDZ domains, a case study.
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PDZ domains and their binding partners: structure, specificity, and modificationCrystallographic and Nuclear Magnetic Resonance Evaluation of the Impact of Peptide Binding to the Second PDZ Domain of Protein Tyrosine Phosphatase 1ENew conformational state of NHERF1-CXCR2 signaling complex captured by crystal lattice trappingDetailed regulatory mechanism of the interaction between ZO-1 PDZ2 and connexin43 revealed by MD simulationsThe role of flexibility and conformational selection in the binding promiscuity of PDZ domainsCharacterization of Promiscuous Binding of Phosphor Ligands to Breast-Cancer-Gene 1 (BRCA1) C-Terminal (BRCT): Molecular Dynamics, Free Energy, Entropy and Inhibitor DesignThe nature of protein domain evolution: shaping the interaction networkBeyond the binding site: the role of the β₂-β₃ loop and extra-domain structures in PDZ domainsProteome scanning to predict PDZ domain interactions using support vector machines.Change in allosteric network affects binding affinities of PDZ domains: analysis through perturbation response scanning.Interaction prediction and classification of PDZ domains.A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding.Molecular recognition in a diverse set of protein-ligand interactions studied with molecular dynamics simulations and end-point free energy calculations.Binding free energy landscape of domain-peptide interactions.Genome-wide analysis of PDZ domain binding reveals inherent functional overlap within the PDZ interaction network.Pyranose dehydrogenase ligand promiscuity: a generalized approach to simulate monosaccharide solvation, binding, and product formation.Detection of persistent organic pollutants binding modes with androgen receptor ligand binding domain by docking and molecular dynamics.Exploring Protein-Peptide Binding Specificity through Computational Peptide ScreeningNMR basis for interprotein electron transfer gating between cytochrome c and cytochrome c oxidase.Achieving peptide binding specificity and promiscuity by loops: case of the forkhead-associated domain.Structural basis for NHERF1 PDZ domain bindingThe PDZ domain as a complex adaptive systemEquilibrium unfolding of the PDZ domain of β2-syntrophinConformational change upon ligand binding and dynamics of the PDZ domain from leukemia-associated Rho guanine nucleotide exchange factorMolecular determinants of binding to the Plasmodium subtilisin-like protease 1.Exploring the molecular design of protein interaction sites with molecular dynamics simulations and free energy calculationsPlasticity of PDZ domains in ligand recognition and signaling.Ionic channels as targets for drug design: a review on computational methods.Computational Investigation of SENP:SUMO Protein-Protein Interaction for Structure Based Drug Design.An optimized MM/PBSA virtual screening approach applied to an HIV-1 gp41 fusion peptide inhibitor.Energetic Mechanism of Cytochrome c-Cytochrome c Oxidase Electron Transfer Complex Formation under Turnover Conditions Revealed by Mutational Effects and Docking Simulation.A flexible docking scheme to explore the binding selectivity of PDZ domains.On the analysis and comparison of conformer-specific essential dynamics upon ligand binding to a protein.Simultaneous prediction of binding free energy and specificity for PDZ domain-peptide interactions.The intracellular region of Notch ligands: does the tail make the difference?High-energy water sites determine peptide binding affinity and specificity of PDZ domains.Interaction investigations of HipA binding to HipB dimer and HipB dimer + DNA complex: a molecular dynamics simulation study.Free energy calculations of the interactions of c-Jun-based synthetic peptides with the c-Fos protein.The evolution of HLA-B*3501 binding affinity to variable immunodominant NP(418-426) peptides from 1918 to 2009 pandemic influenza A virus: a molecular dynamics simulation and free energy calculation study.Molecular dynamics simulation, binding free energy calculation and unbinding pathway analysis on selectivity difference between FKBP51 and FKBP52: Insight into the molecular mechanism of isoform selectivity.
P2860
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P2860
Thermodynamic basis for promiscuity and selectivity in protein-protein interactions: PDZ domains, a case study.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Thermodynamic basis for promis ...... ns: PDZ domains, a case study.
@en
type
label
Thermodynamic basis for promis ...... ns: PDZ domains, a case study.
@en
prefLabel
Thermodynamic basis for promis ...... ns: PDZ domains, a case study.
@en
P2093
P2860
P356
P1476
Thermodynamic basis for promis ...... ns: PDZ domains, a case study.
@en
P2093
Harel Weinstein
Marco Ceruso
Nathalie Basdevant
P2860
P304
12766-12777
P356
10.1021/JA060830Y
P407
P577
2006-10-01T00:00:00Z