The Nrf2 activator oltipraz also activates the constitutive androstane receptor. - Test2 - elhamkhani - TriplyDB

The Nrf2 activator oltipraz also activates the constitutive androstane receptor.

The Nrf2 activator oltipraz also activates the constitutive androstane receptor.

http://www.wikidata.org/entity/Q36957687

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Activation of xenobiotic receptors: driving into the nucleus.Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice.Beneficial role of Nrf2 in regulating NADPH generation and consumption.Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice.Genome-wide analysis of human constitutive androstane receptor (CAR) transcriptome in wild-type and CAR-knockout HepaRG cells Bakuchiol Is a Phenolic Isoprenoid with Novel Enantiomer-selective Anti-influenza A Virus Activity Involving Nrf2 Activation.Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice.Salvianolic Acid B Prevents Iodinated Contrast Media-Induced Acute Renal Injury in Rats via the PI3K/Akt/Nrf2 Pathway Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species.Chemical genomics of cancer chemopreventive dithiolethiones.Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.Nuclear translocation of adenoviral-enhanced yellow fluorescent protein-tagged-human constitutive androstane receptor (hCAR): a novel tool for screening hCAR activators in human primary hepatocytes.Nrf2 the rescue: effects of the antioxidative/electrophilic response on the liver.Hydrodynamic gene delivery and its applications in pharmaceutical research.The Effects of Oltipraz on Tissue Regeneration in the Process of Wound Healing: A Stereological Study.Nrf2 activators as potential modulators of injury in human kidney cells.Possible involvement of nuclear factor erythroid 2-related factor 2 in the gene expression of Cyp2b10 and Cyp2a5.The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice.Gender-specific expression of ATP-binding cassette (Abc) transporters and cytoprotective genes in mouse choroid plexus.

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The Nrf2 activator oltipraz also activates the constitutive androstane receptor.

http://www.wikidata.org/entity/Q36957687

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

The Nrf2 activator oltipraz also activates the constitutive androstane receptor.

@en

type

label

The Nrf2 activator oltipraz also activates the constitutive androstane receptor.

@en

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The Nrf2 activator oltipraz also activates the constitutive androstane receptor.

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Drug Metabolism and Disposition

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The Nrf2 activator oltipraz also activates the constitutive androstane receptor.

@en

P2093

Angela L Slitt

http://www.w3.org/2001/XMLSchema#string

Craig D Fisher

http://www.w3.org/2001/XMLSchema#string

Curtis D Klaassen

http://www.w3.org/2001/XMLSchema#string

David D Moore

http://www.w3.org/2001/XMLSchema#string

Jonathan M Maher

http://www.w3.org/2001/XMLSchema#string

Jonathan P Jackson

http://www.w3.org/2001/XMLSchema#string

Lisa M Augustine

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Matthew D Merrell

http://www.w3.org/2001/XMLSchema#string

Nathan J Cherrington

http://www.w3.org/2001/XMLSchema#string

Wendong Huang

http://www.w3.org/2001/XMLSchema#string

P2860

The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats

Mechanistic studies of the Nrf2-Keap1 signaling pathway

Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione

Induction of drug metabolism enzymes and transporters by oltipraz in rats

Isolation of cDNAs representing dithiolethione-responsive genes

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

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1716-1721

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scholarly article

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10.1124/DMD.108.020867

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8

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36

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2008-05-12T00:00:00Z

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18474683

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3693743

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