Staged assembly of histone gene expression machinery at subnuclear foci in the abbreviated cell cycle of human embryonic stem cells - Test2 - elhamkhani - TriplyDB

Staged assembly of histone gene expression machinery at subnuclear foci in the abbreviated cell cycle of human embryonic stem cells

Staged assembly of histone gene expression machinery at subnuclear foci in the abbreviated cell cycle of human embryonic stem cells

http://www.wikidata.org/entity/Q36964278

about

FLASH is essential during early embryogenesis and cooperates with p73 to regulate histone gene transcription The Cajal body and histone locus body Three proteins of the U7-specific Sm ring function as the molecular ruler to determine the site of 3'-end processing in mammalian histone pre-mRNA Small Cajal body-specific RNAs of Drosophila function in the absence of Cajal bodies The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles The architectural organization of human stem cell cycle regulatory machinery Dynamic control of Cajal body number during zebrafish embryogenesis.Human embryonic stem cells are pre-mitotically committed to self-renewal and acquire a lengthened G1 phase upon lineage programming Persistent replicative stress alters polycomb phenotypes and tissue homeostasis in Drosophila melanogaster.Fidelity of histone gene regulation is obligatory for genome replication and stability.CstF-64 supports pluripotency and regulates cell cycle progression in embryonic stem cells through histone 3' end processing.The role of nuclear bodies in gene expression and disease.Survival responses of human embryonic stem cells to DNA damage.Comparative ultrastructure of CRM1-Nucleolar bodies (CNoBs), Intranucleolar bodies (INBs) and hybrid PML/p62 bodies uncovers new facets of nuclear body dynamic and diversity Reprogramming the pluripotent cell cycle: restoration of an abbreviated G1 phase in human induced pluripotent stem (iPS) cells.A conserved interaction that is essential for the biogenesis of histone locus bodies.Cyclin D2 and the CDK substrate p220(NPAT) are required for self-renewal of human embryonic stem cells.Random mitotic activities across human embryonic stem cell colonies.Drosophila histone locus bodies form by hierarchical recruitment of components The subnuclear organization of histone gene regulatory proteins and 3' end processing factors of normal somatic and embryonic stem cells is compromised in selected human cancer cell types.Cell cycle gene expression networks discovered using systems biology: Significance in carcinogenesis INT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation.p53 checkpoint ablation exacerbates the phenotype of Hinfp dependent histone H4 deficiency.Human embryonic stem cell responses to ionizing radiation exposures: current state of knowledge and future challenges Epigenetic control of cell cycle-dependent histone gene expression is a principal component of the abbreviated pluripotent cell cycle.A sequence in the Drosophila H3-H4 Promoter triggers histone locus body assembly and biosynthesis of replication-coupled histone mRNAs Non-coding RNAs, the cutting edge of histone messages.The abbreviated pluripotent cell cycle.Concentrating pre-mRNA processing factors in the histone locus body facilitates efficient histone mRNA biogenesis.Lessons learned about human stem cell responses to ionizing radiation exposures: a long road still ahead of us.Concise Review: Control of Cell Fate Through Cell Cycle and Pluripotency Networks.Cajal bodies: where form meets function.Activation of transcription enforces the formation of distinct nuclear bodies in zebrafish embryos.FLASH degradation in response to UV-C results in histone locus bodies disruption and cell-cycle arrest.Mapping the Interaction Network of Key Proteins Involved in Histone mRNA Generation: A Hydrogen/Deuterium Exchange Study.Interaction between FLASH and Lsm11 is essential for histone pre-mRNA processing in vivo in Drosophila Coordinate regulation of histone mRNA metabolism and DNA replication: cyclin A/cdk1 is involved in inactivation of histone mRNA metabolism and DNA replication at the end of S phase.The Y3** ncRNA promotes the 3' end processing of histone mRNAs.FLASH, a proapoptotic protein involved in activation of caspase-8, is essential for 3' end processing of histone pre-mRNAs.Specific genomic cues regulate Cajal body assembly

P2860

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P2860

Staged assembly of histone gene expression machinery at subnuclear foci in the abbreviated cell cycle of human embryonic stem cells

http://www.wikidata.org/entity/Q36964278

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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Staged assembly of histone gen ...... of human embryonic stem cells

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Staged assembly of histone gen ...... of human embryonic stem cells

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PNAS.0809273105

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Proceedings of the National Academy of Sciences of the United States of America

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Staged assembly of histone gen ...... of human embryonic stem cells

@en

P2093

Andre J van Wijnen

http://www.w3.org/2001/XMLSchema#string

Gary S Stein

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Jane B Lian

http://www.w3.org/2001/XMLSchema#string

Janet L Stein

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Klaus A Becker

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Prachi N Ghule

http://www.w3.org/2001/XMLSchema#string

William F Marzluff

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Xiao-Cui Yang

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Zbigniew Dominski

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P2860

Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription

Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein

A 3' exonuclease that specifically interacts with the 3' end of histone mRNA

Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase

The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes

Nuclear import of the stem-loop binding protein and localization during the cell cycle.

HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition.

Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing

Coiled bodies contain U7 small nuclear RNA and associate with specific DNA sequences in interphase human cells

NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

P304

16964-16969

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scholarly article

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10.1073/PNAS.0809273105

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44

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P478

105

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Jeffrey W. Harper

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2008-10-28T00:00:00Z

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23425236

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18957539

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2579361

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