Direct demonstration of separate receptors for growth and metabolic activities of insulin and multiplication-stimulating activity (an insulinlike growth factor) using antibodies to the insulin receptor.
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Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblastsReplacement of insulin receptor tyrosine residues 1162 and 1163 does not alter the mitogenic effect of the hormone.Mechanisms subserving the trophic actions of insulin on ovarian cells. In vitro studies using swine granulosa cells.Insulin-like growth factor I stimulates lipid oxidation, reduces protein oxidation, and enhances insulin sensitivity in humansA transgene coding for a human insulin analog has a mitogenic effect on murine embryonic beta cellsComparison of the metabolic effects of recombinant human insulin-like growth factor-I and insulin. Dose-response relationships in healthy young and middle-aged adults.Intravenously injected insulin-like growth factor (IGF) I/IGF binding protein-3 complex exerts insulin-like effects in hypophysectomized, but not in normal rats.Effects of insulin-like growth factor-I on glucose tolerance, insulin levels, and insulin secretion.In situ autoradiography and ligand-dependent tyrosine kinase activity reveal insulin receptors and insulin-like growth factor I receptors in prepancreatic chicken embryosThe insulin receptor as a transmitter of a mitogenic signal in Chinese hamster ovary CHO-K1 cells.Modulation of insulinlike growth factor I binding to human fibroblast monolayer cultures by insulinlike growth factor carrier proteins released to the incubation mediaLung fibroblasts from patients with emphysema show markers of senescence in vitro.Receptors and growth-promoting effects of insulin and insulinlike growth factors on cells from bovine retinal capillaries and aorta.Selective suppression of insulin-induced proliferation of cultured human hepatoma cells by somatostatin.Insulin-like growth factor-I can mediate autocrine proliferation of human small cell lung cancer cell lines in vitro.Structural and functional characterization of the human T lymphocyte receptor for insulin-like growth factor I in vitroIdentification of persistent defects in insulin receptor structure and function capillary endothelial cells from diabetic rats.Acute effects of insulin-like growth factor I on glucose and amino acid metabolism in the awake fasted rat. Comparison with insulin.Dual regulation of glycogen metabolism by insulin and insulin-like growth factors in human hepatoma cells (HEP-G2). Analysis with an anti-receptor monoclonal antibody.Regulation of insulin-like growth factor II receptors by growth hormone and insulin in rat adipocytes.Differential responsiveness to insulin of endothelial and support cells from micro- and macrovessels.Somatomedin receptor of human placenta: solubilization, photolabeling, partial purification, and comparison with insulin receptor.Can "big" insulin-like growth factor II in serum of tumor patients account for the development of extrapancreatic tumor hypoglycemia?Insulin activates the appearance of insulin-like growth factor II receptors on the adipocyte cell surface.Insulin is essential for accumulation of casein mRNA in mouse mammary epithelial cells.Activation of the ribosomal DNA promoter in cells exposed to insulinlike growth factor I.Decreased sensitivity of old and progeric human fibroblasts to a preparation of factors with insulinlike activity.Receptors for insulinlike growth factor I are defective in fibroblasts cultured from a patient with leprechaunism.Antibody-induced desensitization of the insulin receptor. Studies of the mechanism of desensitization in 3T3-L1 fatty fibroblasts.Insulin resistance and hyperinsulinaemia in the development and progression of cancer.Phorbol 12-myristate 13-acetate and insulin increase the concentration of fructose 2,6-bisphosphate and stimulate glycolysis in chicken embryo fibroblasts.Growth hormone and insulin-like growth factors I and II produce distinct alterations in glucose metabolism in 3T3-F442A adipocytesSharing of biological effect and receptors between guinea pig insulin and platelet-derived growth factor.The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices.Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression.Insulin-like growth factor binding protein-3 enhances etoposide-induced cell growth inhibition by suppressing the NF-κB activity in gastric cancer cells.Mitogenic response of canine fundic epithelial cells in short-term culture to transforming growth factor alpha and insulinlike growth factor I.The effects of infusion of insulinlike growth factor (IGF) I, IGF-II, and insulin on glucose and protein metabolism in fasted lambs.Vascular actions of insulin in health and disease.Characterization and partial purification of an endothelial cell growth factor from human platelets.
P2860
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P2860
Direct demonstration of separate receptors for growth and metabolic activities of insulin and multiplication-stimulating activity (an insulinlike growth factor) using antibodies to the insulin receptor.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 1980
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Direct demonstration of separa ...... odies to the insulin receptor.
@en
Direct demonstration of separa ...... plication-stimulating activity
@nl
type
label
Direct demonstration of separa ...... odies to the insulin receptor.
@en
Direct demonstration of separa ...... plication-stimulating activity
@nl
prefLabel
Direct demonstration of separa ...... odies to the insulin receptor.
@en
Direct demonstration of separa ...... plication-stimulating activity
@nl
P2093
P2860
P356
P1476
Direct demonstration of separa ...... odies to the insulin receptor.
@en
P2093
P2860
P304
P356
10.1172/JCI109826
P407
P577
1980-07-01T00:00:00Z