Acute cellular uptake of abnormal prion protein is cell type and scrapie-strain independent.
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Cellular aspects of prion replication in vitroThe strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of diseaseRecombinant prion protein refolded with lipid and RNA has the biochemical hallmarks of a prion but lacks in vivo infectivityGetting a grip on prions: oligomers, amyloids, and pathological membrane interactions.Characterization of intracellular dynamics of inoculated PrP-res and newly generated PrP(Sc) during early stage prion infection in Neuro2a cells.The role of the prion protein membrane anchor in prion infection.Uptake and degradation of protease-sensitive and -resistant forms of abnormal human prion protein aggregates by human astrocytes.Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction.Prion protein biosynthesis and its emerging role in neurodegeneration.The Prion Protein N1 and N2 Cleavage Fragments Bind to Phosphatidylserine and Phosphatidic Acid; Relevance to Stress-Protection ResponsesRabbits are not resistant to prion infectionModulation of Glycosaminoglycans Affects PrPSc Metabolism but Does Not Block PrPSc Uptake.PrPSc formation and clearance as determinants of prion tropism.Disease-associated mutations in the prion protein impair laminin-induced process outgrowth and survivalCells expressing anchorless prion protein are resistant to scrapie infection.A specific population of abnormal prion protein aggregates is preferentially taken up by cells and disaggregated in a strain-dependent manner.Human tonsil-derived follicular dendritic-like cells are refractory to human prion infection in vitro and traffic disease-associated prion protein to lysosomes.Prion-like propagation of cytosolic protein aggregates: insights from cell culture models.Prions Ex Vivo: What Cell Culture Models Tell Us about Infectious Proteins.Prion strains depend on different endocytic routes for productive infection.MEK1 transduces the prion protein N2 fragment antioxidant effects.Prions on the run: How extracellular vesicles serve as delivery vehicles for self-templating protein aggregatesAlteration of cell responses to PrP(Sc) in prolonged cell culture and its effect on transmission of PrP(Sc) to neural cells.Cell Biology Approaches to Studying Prion Diseases.Neuronal low-density lipoprotein receptor-related protein 1 binds and endocytoses prion fibrils via receptor cluster 4.Prion-induced and spontaneous formation of transmissible toxicity in PrP transgenic Drosophila.Human embryonic stem cells rapidly take up and then clear exogenous human and animal prions in vitro.Prion acute synaptotoxicity is largely driven by protease-resistant PrPSc species
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P2860
Acute cellular uptake of abnormal prion protein is cell type and scrapie-strain independent.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 08 August 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Acute cellular uptake of abnor ...... nd scrapie-strain independent.
@en
Acute cellular uptake of abnor ...... nd scrapie-strain independent.
@nl
type
label
Acute cellular uptake of abnor ...... nd scrapie-strain independent.
@en
Acute cellular uptake of abnor ...... nd scrapie-strain independent.
@nl
prefLabel
Acute cellular uptake of abnor ...... nd scrapie-strain independent.
@en
Acute cellular uptake of abnor ...... nd scrapie-strain independent.
@nl
P2093
P2860
P1433
P1476
Acute cellular uptake of abnor ...... and scrapie-strain independent
@en
P2093
Anne E Ward
Christopher S Greil
Ina M Vorberg
Kimberly D Meade-White
Suzette A Priola
P2860
P304
P356
10.1016/J.VIROL.2008.07.006
P407
P577
2008-08-08T00:00:00Z