Eukaryotic DNA damage tolerance and translesion synthesis through covalent modifications of PCNA.
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Human single-stranded DNA binding proteins are essential for maintaining genomic stabilityCRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesisEvidence for the involvement of human DNA polymerase N in the repair of DNA interstrand cross-linksEukaryotic translesion polymerases and their roles and regulation in DNA damage toleranceCoordination of DNA damage tolerance mechanisms with cell cycle progression in fission yeast.A broad requirement for TLS polymerases η and κ, and interacting sumoylation and nuclear pore proteins, in lesion bypass during C. elegans embryogenesisStructural Insight into Translesion Synthesis by DNA Pol IILocalization of recombination proteins and Srs2 reveals anti-recombinase function in vivo.Reversal of PCNA ubiquitylation by Ubp10 in Saccharomyces cerevisiae.Genetic instability in budding and fission yeast-sources and mechanismsA novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phaseThe tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progressionDNA damage alters DNA polymerase delta to a form that exhibits increased discrimination against modified template bases and mismatched primersProteomic changes in rat spermatogenesis in response to in vivo androgen manipulation; impact on meiotic cellsThe mutational spectrum of non-CpG DNA varies with CpG contentA chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA.Dissection of DNA damage responses using multiconditional genetic interaction mapsREV3L confers chemoresistance to cisplatin in human gliomas: the potential of its RNAi for synergistic therapyPost-replication repair suppresses duplication-mediated genome instabilityExpression of a novel peptide derived from PCNA damages DNA and reverses cisplatin resistance.Both RAD5-dependent and independent pathways are involved in DNA damage-associated sister chromatid exchange in budding yeast.Fission yeast Hsk1 (Cdc7) kinase is required after replication initiation for induced mutagenesis and proper response to DNA alkylation damage.Characterization of four rice UEV1 genes required for Lys63-linked polyubiquitination and distinct functionsAberrant expression of regulators of cell-fate found in eutopic endometrium is found in matched ectopic endometrium among women and in a baboon model of endometriosis.Chronic low-dose ultraviolet-induced mutagenesis in nucleotide excision repair-deficient cellsSpatiotemporal recruitment of human DNA polymerase delta to sites of UV damage.Repair of naturally occurring mismatches can induce mutations in flanking DNA.The DNA polymerase activity of Saccharomyces cerevisiae Rev1 is biologically significant.Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival.Roles of the Werner syndrome RecQ helicase in DNA replication.Branching out with DNA helicases.RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forksThe yeast Shu complex utilizes homologous recombination machinery for error-free lesion bypass via physical interaction with a Rad51 paralogue.Sequential assembly of translesion DNA polymerases at UV-induced DNA damage sitesDNA Damage Responses Are Induced by tRNA Anticodon Nucleases and Hygromycin B.Epidermal growth factor receptor protects proliferating cell nuclear antigen from cullin 4A protein-mediated proteolysis.The effect of acetaminophen on ubiquitin homeostasis in Saccharomyces cerevisiaeIdentification of RNF8 as a ubiquitin ligase involved in targeting the p12 subunit of DNA polymerase δ for degradation in response to DNA damageNoncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly.Arabidopsis ubiquitin-conjugating enzyme UBC22 is required for female gametophyte development and likely involved in Lys11-linked ubiquitination.
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Eukaryotic DNA damage tolerance and translesion synthesis through covalent modifications of PCNA.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Eukaryotic DNA damage toleranc ...... ovalent modifications of PCNA.
@en
Eukaryotic DNA damage toleranc ...... ovalent modifications of PCNA.
@nl
type
label
Eukaryotic DNA damage toleranc ...... ovalent modifications of PCNA.
@en
Eukaryotic DNA damage toleranc ...... ovalent modifications of PCNA.
@nl
prefLabel
Eukaryotic DNA damage toleranc ...... ovalent modifications of PCNA.
@en
Eukaryotic DNA damage toleranc ...... ovalent modifications of PCNA.
@nl
P2860
P356
P1433
P1476
Eukaryotic DNA damage toleranc ...... ovalent modifications of PCNA.
@en
P2093
Parker L Andersen
P2860
P2888
P304
P356
10.1038/CR.2007.114
P50
P577
2008-01-01T00:00:00Z
P5875
P6179
1045316563