Syndromic deafness mutations at Asn 14 differentially alter the open stability of Cx26 hemichannels. - Test2 - elhamkhani - TriplyDB

Syndromic deafness mutations at Asn 14 differentially alter the open stability of Cx26 hemichannels.

Syndromic deafness mutations at Asn 14 differentially alter the open stability of Cx26 hemichannels.

http://www.wikidata.org/entity/Q37047097

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Critical role of ATP-induced ATP release for Ca2+ signaling in nonsensory cell networks of the developing cochlea.Human diseases associated with connexin mutations.Gap junction structure: unraveled, but not fully revealed.Altered CO2 sensitivity of connexin26 mutant hemichannels in vitro Connexin hemichannels and cochlear function.Induction of cell death and gain-of-function properties of connexin26 mutants predict severity of skin disorders and hearing loss.Deafness-associated mutation opens the gate to understanding.The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels.Cues to Opening Mechanisms From in Silico Electric Field Excitation of Cx26 Hemichannel and in Vitro Mutagenesis Studies in HeLa Transfectans.

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Syndromic deafness mutations at Asn 14 differentially alter the open stability of Cx26 hemichannels.

http://www.wikidata.org/entity/Q37047097

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on July 2016

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Syndromic deafness mutations a ...... tability of Cx26 hemichannels.

@en

Syndromic deafness mutations a ...... tability of Cx26 hemichannels.

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type

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Syndromic deafness mutations a ...... tability of Cx26 hemichannels.

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Syndromic deafness mutations a ...... tability of Cx26 hemichannels.

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Syndromic deafness mutations a ...... tability of Cx26 hemichannels.

@en

Syndromic deafness mutations a ...... tability of Cx26 hemichannels.

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The Journal of General Physiology

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Syndromic deafness mutations a ...... tability of Cx26 hemichannels.

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Helmuth A Sanchez

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Miduturu Srinivas

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Nefeli Slavi

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Vytas K Verselis

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P2860

The role of connexins in ear and skin physiology - functional insights from disease-associated mutations

Aberrant Cx26 hemichannels and keratitis-ichthyosis-deafness syndrome: insights into syndromic hearing loss

Keratitis-ichthyosis-deafness syndrome-associated Cx26 mutants produce nonfunctional gap junctions but hyperactive hemichannels when co-expressed with wild type Cx43.

Structure of the connexin 26 gap junction channel at 3.5 A resolution

Altered inhibition of Cx26 hemichannels by pH and Zn2+ in the A40V mutation associated with keratitis-ichthyosis-deafness syndrome

Identification of a pore lining segment in gap junction hemichannels.

Differentially altered Ca2+ regulation and Ca2+ permeability in Cx26 hemichannels formed by the A40V and G45E mutations that cause keratitis ichthyosis deafness syndrome

Localization of a voltage gate in connexin46 gap junction hemichannels.

Reversal of the gating polarity of gap junctions by negative charge substitutions in the N-terminus of connexin 32

The first extracellular loop domain is a major determinant of charge selectivity in connexin46 channels.

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25-42

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scholarly article

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10.1085/JGP.201611585

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1

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148

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2016-07-01T00:00:00Z

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27353444

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4924935

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