The CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapy

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WNK Kinases in Development and Disease.Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects.Mechanisms and controversies in mutant Cul3-mediated Familial Hyperkalemic Hypertension.

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The CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapy

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 13 April 2016

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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The CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapy

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The CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapy.

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The CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapy

@en

The CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapy.

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The CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapy

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The CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapy.

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The CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapy

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James A McCormick

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MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters

Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies

STK39 polymorphism is associated with essential hypertension: a systematic review and meta-analysis

A Randomized Trial of Intensive versus Standard Blood-Pressure Control

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F1389-96

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scholarly article

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10.1152/AJPRENAL.00132.2016

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310

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Mohammed Zubaerul Ferdaus

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2016-04-13T00:00:00Z

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27076645

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4935775

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The CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapy

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The CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapy

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P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P698

P932