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Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examplesPlant cell nucleolus as a hot spot for ironRole of ROS and RNS Sources in Physiological and Pathological ConditionsCathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug CandidateTyrosine modifications in agingThe type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channelEnhanced lysosomal activity is involved in Bax inhibitor-1-induced regulation of the endoplasmic reticulum (ER) stress response and cell death against ER stress: involvement of vacuolar H+-ATPase (V-ATPase).Amyloid precursor protein, lipofuscin accumulation and expression of autophagy markers in aged bovine brain.Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders.Aberrant Ca2+ handling in lysosomal storage disordersTargeted radionuclide therapy with astatine-211: Oxidative dehalogenation of astatobenzoate conjugates.Mucolipins: Intracellular TRPML1-3 channelsFluorescent sensors for measuring metal ions in living systemsMitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol.TRP channels of intracellular membranesThe pallidopyramidal syndromes: nosology, aetiology and pathogenesis.The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity.Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress.Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species productionAutophagy failure in Alzheimer's disease--locating the primary defect.Eucommia ulmoides Oliver extract, aucubin, and geniposide enhance lysosomal activity to regulate ER stress and hepatic lipid accumulationmiR-210 targets iron-sulfur cluster scaffold homologue in human trophoblast cell lines: siderosis of interstitial trophoblasts as a novel pathology of preterm preeclampsia and small-for-gestational-age pregnancies.Telomerase deficiency delays renal recovery in mice after ischemia-reperfusion injury by impairing autophagyThe endocytic pathway in microglia during health, aging and Alzheimer's disease.Discerning the Chemistry in Individual Organelles with Small-Molecule Fluorescent Probes.A novel method for autophagy detection in primary cells: impaired levels of macroautophagy in immunosenescent T cellsTransition metals activate TFEB in overexpressing cellsIron-Mediated Lysosomal Membrane Permeabilization in Ethanol-Induced Hepatic Oxidative Damage and Apoptosis: Protective Effects of Quercetin.Aggregatibacter actinomycetemcomitans leukotoxin induces cytosol acidification in LFA-1 expressing immune cells.The Induction of Oxidative/Nitrosative Stress, Inflammation, and Apoptosis by a Ferric Carboxymaltose Copy Compared to Iron Sucrose in a Non-Clinical Model.The position of lysosomes within the cell determines their luminal pHHepatic reticuloendothelial system cell iron deposition is associated with increased apoptosis in nonalcoholic fatty liver diseaseFerritinophagy drives uropathogenic Escherichia coli persistence in bladder epithelial cellsAutophagy-physiology and pathophysiology.Lipofuscin: formation, effects and role of macroautophagyEffect of gadolinium-based nanoparticles on nuclear DNA damage and repair in glioblastoma tumor cellsA general map of iron metabolism and tissue-specific subnetworks.Mobilization of stored iron in mammals: a review.Profound morphological changes in the erythrocytes and fibrin networks of patients with hemochromatosis or with hyperferritinemia, and their normalization by iron chelators and other agents.Lysosomes as "suicide bags" in cell death: myth or reality?
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 08 February 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Lysosomes in iron metabolism, ageing and apoptosis.
@en
Lysosomes in iron metabolism, ageing and apoptosis.
@nl
type
label
Lysosomes in iron metabolism, ageing and apoptosis.
@en
Lysosomes in iron metabolism, ageing and apoptosis.
@nl
prefLabel
Lysosomes in iron metabolism, ageing and apoptosis.
@en
Lysosomes in iron metabolism, ageing and apoptosis.
@nl
P2093
P2860
P921
P1476
Lysosomes in iron metabolism, ageing and apoptosis.
@en
P2093
Alexei Terman
Bertil Gustafsson
Ulf T Brunk
P2860
P2888
P304
P356
10.1007/S00418-008-0394-Y
P577
2008-02-08T00:00:00Z
2008-04-01T00:00:00Z