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Unraveling genetic origin of aging-related traits: evolving concepts

Unraveling genetic origin of aging-related traits: evolving concepts

http://www.wikidata.org/entity/Q37102186

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Detection of a novel, integrative aging process suggests complex physiological integration Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study.Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies.Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.Explicating heterogeneity of complex traits has strong potential for improving GWAS efficiency.Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan.Uncoupling associations of risk alleles with endophenotypes and phenotypes: insights from the ApoB locus and heart-related traits.Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study.Identification of polymorphisms in cancer patients that differentially affect survival with age.Strong impact of natural-selection-free heterogeneity in genetics of age-related phenotypes.

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Unraveling genetic origin of aging-related traits: evolving concepts

http://www.wikidata.org/entity/Q37102186

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on August 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Unraveling genetic origin of aging-related traits: evolving concepts

@en

Unraveling genetic origin of aging-related traits: evolving concepts.

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type

label

Unraveling genetic origin of aging-related traits: evolving concepts

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Unraveling genetic origin of aging-related traits: evolving concepts.

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prefLabel

Unraveling genetic origin of aging-related traits: evolving concepts

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Unraveling genetic origin of aging-related traits: evolving concepts.

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Rejuvenation Research

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Unraveling genetic origin of aging-related traits: evolving concepts

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Alexander M Kulminski

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Biological, clinical and population relevance of 95 loci for blood lipids

Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects

FOXO3A genotype is strongly associated with human longevity

The human disease network

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2013-08-01T00:00:00Z

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