Location and properties of metal-binding sites on the human prion protein.
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Studies of the transmissibility of the agent of bovine spongiform encephalopathy to the domestic chickenCellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomersMolecular features of the copper binding sites in the octarepeat domain of the prion proteinProbing the role of PrP repeats in conformational conversion and amyloid assembly of chimeric yeast prionsThe role of the cellular prion protein in the immune systemCopper signaling in the mammalian nervous system: synaptic effectsNeuronal zinc regulation and the prion proteinThe prion protein binds thiamineHigh content screening in zebrafish speeds up hazard ranking of transition metal oxide nanoparticlesThe PrP-like protein Doppel binds copperPrion fragment peptides are digested with membrane type matrix metalloproteinases and acquire enzyme resistance through Cu²⁺-bindingComparative analysis of the human and chicken prion protein copper binding regions at pH 6.5.Anion effects on sodium ion and acid molecule adduction to protein ions in electrospray ionization mass spectrometry.Utilizing NMR and EPR spectroscopy to probe the role of copper in prion diseases.Mapping Cu(II) binding sites in prion proteins by diethyl pyrocarbonate modification and matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometric footprinting.Binding of alpha-synuclein with Fe(III) and with Fe(II) and biological implications of the resultant complexes.Insights into prion protein function from atomistic simulations.Redox control of prion and disease pathogenesis.Evolutionary implications of metal binding features in different species' prion protein: an inorganic point of view.Gerstmann-Straüssler-Scheinker disease: novel PRNP mutation and VGKC-complex antibodies.ESEEM analysis of multi-histidine Cu(II)-coordination in model complexes, peptides, and amyloid-βStability and Cu(II) binding of prion protein variants related to inherited human prion diseases.Conformation of prion protein repeat peptides probed by FRET measurements and molecular dynamics simulations.The prion protein family: a view from the placentaIdentification and characterization of a copper-binding site in αA-crystallin.Combined EXAFS and DFT structure calculations provide structural insights into the 1:1 multi-histidine complexes of Cu(II) , Cu(I) , and Zn(II) with the tandem octarepeats of the mammalian prion proteinCalorimetric investigation of copper binding in the N-terminal region of the prion protein at low copper loading: evidence for an entropically favorable first binding event.Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sitesOctarepeat region flexibility impacts prion function, endoproteolysis and disease manifestationMolecular neurology of prion disease.Infectious prion protein alters manganese transport and neurotoxicity in a cell culture model of prion disease.Copper alters aggregation behavior of prion protein and induces novel interactions between its N- and C-terminal regions.Copper binding in the prion proteinA Structural and Functional Comparison Between Infectious and Non-Infectious Autocatalytic Recombinant PrP Conformers.Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptorsPrion Protein Does Not Confer Resistance to Hippocampus-Derived Zpl Cells against the Toxic Effects of Cu2+, Mn2+, Zn2+ and Co2+ Not Supporting a General Protective Role for PrP in Transition Metal Induced Toxicity.The cellular prion protein (PrP(C)): its physiological function and role in diseaseCopper-induced structural conversion templates prion protein oligomerization and neurotoxicity.Cellular prion protein: A co-receptor mediating neuronal cofilin-actin rod formation induced by β-amyloid and proinflammatory cytokines.Effect of divalent metals on the neuronal proteasomal system, prion protein ubiquitination and aggregation.
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P2860
Location and properties of metal-binding sites on the human prion protein.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 03 July 2001
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
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name
Location and properties of metal-binding sites on the human prion protein.
@en
Location and properties of metal-binding sites on the human prion protein.
@nl
type
label
Location and properties of metal-binding sites on the human prion protein.
@en
Location and properties of metal-binding sites on the human prion protein.
@nl
prefLabel
Location and properties of metal-binding sites on the human prion protein.
@en
Location and properties of metal-binding sites on the human prion protein.
@nl
P2093
P2860
P356
P1476
Location and properties of metal-binding sites on the human prion protein
@en
P2093
P2860
P304
P356
10.1073/PNAS.151038498
P407
P577
2001-07-03T00:00:00Z