Multiple pathways regulated by the tumor suppressor PP2A in transformation.
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ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2ALIM domain protein FHL1B interacts with PP2A catalytic β subunit--a novel cell cycle regulatory pathwayAn integrated workflow for charting the human interaction proteome: insights into the PP2A systemPME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant gliomaIdentification of protein interactions involved in cellular signalingProtein kinases and phosphatases in the control of cell fateTargeting protein serine/threonine phosphatases for drug developmentThe broken "Off" switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillanceThe emerging role of FTY720 (Fingolimod) in cancer treatmentProtein Phosphatase 2A as a Therapeutic Target in Acute Myeloid LeukemiaThe biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificityWhat goes on must come off: phosphatases gate-crash the DNA damage responsePPP2R5C Couples Hepatic Glucose and Lipid HomeostasisInhibition of Receptor Dimerization as a Novel Negative Feedback Mechanism of EGFR SignalingPP2A: The Achilles Heal in MDS with 5q DeletionThe potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signallingThe Basic Biology of PP2A in Hematologic Cells and MalignanciesPP2A: The Wolf in Sheep's Clothing?Computer-aided targeting of the PI3K/Akt/mTOR pathway: toxicity reduction and therapeutic opportunitiesThe Human Adenovirus Type 5 E4orf4 Protein Targets Two Phosphatase Regulators of the Hippo Signaling PathwayCIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in miceProtein phosphatase 2A promotes the transition to G0 during terminal differentiation in DrosophilaRegulation of c-Myc Protein Abundance by a Protein Phosphatase 2A-Glycogen Synthase Kinase 3β-Negative Feedback Pathway.Mitotic catastrophe triggered in human cancer cells by the viral protein apoptin.Integrated analysis of genome-wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype-negative colon cancer.Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells.Physiological regulation of Akt activity and stability.Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylationTargeting c-MYC by antagonizing PP2A inhibitors in breast cancer.Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1.Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancerErlotinib derivative inhibits hepatocellular carcinoma by targeting CIP2A to reactivate protein phosphatase 2A.From the Biology of PP2A to the PADs for Therapy of Hematologic MalignanciesPhosphorylated protein phosphatase 2A determines poor outcome in patients with metastatic colorectal cancer.Gene dysregulations driven by somatic copy number aberrations-biological and clinical implications in colon tumors: a paper from the 2009 William Beaumont Hospital Symposium on Molecular Pathology.CIP2A regulates cell proliferation via the AKT signaling pathway in human lung cancer.Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E.Cdc55 coordinates spindle assembly and chromosome disjunction during meiosis.Differential regulation of cutaneous oncoprotein HPVE6 by wtp53, mutant p53R248W and ΔNp63α is HPV type dependent.Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair.
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P2860
Multiple pathways regulated by the tumor suppressor PP2A in transformation.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 10 March 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Multiple pathways regulated by the tumor suppressor PP2A in transformation.
@en
Multiple pathways regulated by the tumor suppressor PP2A in transformation.
@nl
type
label
Multiple pathways regulated by the tumor suppressor PP2A in transformation.
@en
Multiple pathways regulated by the tumor suppressor PP2A in transformation.
@nl
prefLabel
Multiple pathways regulated by the tumor suppressor PP2A in transformation.
@en
Multiple pathways regulated by the tumor suppressor PP2A in transformation.
@nl
P1476
Multiple pathways regulated by the tumor suppressor PP2A in transformation.
@en
P2093
Jukka Westermarck
William C Hahn
P304
P356
10.1016/J.MOLMED.2008.02.001
P577
2008-03-10T00:00:00Z