Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments. - Test2 - elhamkhani - TriplyDB

Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments.

Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments.

http://www.wikidata.org/entity/Q37111862

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Next-generation sequencing: a powerful tool for the discovery of molecular markers in breast ductal carcinoma in situ Ways to enhance lymphocyte trafficking into tumors and fitness of tumor infiltrating lymphocytes Broad targeting of angiogenesis for cancer prevention and therapy Impact of metabolic heterogeneity on tumor growth, invasion, and treatment outcomes.Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment Janus-faced tumor microenvironment and redox Investigating Effects of Acidic pH on Proliferation, Invasion and Drug-Induced Apoptosis in Lymphoblastic Leukemia.Targeting Acidity in Pancreatic Adenocarcinoma: Multispectral Optoacoustic Tomography Detects pH-Low Insertion Peptide Probes In Vivo.Rapid uptake of glucose and lactate, and not hypoxia, induces apoptosis in three-dimensional tumor tissue culture Compromised blood-brain barrier competence in remote brain areas in ischemic stroke rats at the chronic stage Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress.Autophagic clearance of mitochondria in the kidney copes with metabolic acidosis.Acidity generated by the tumor microenvironment drives local invasion Genetic variants associated with increased risk of malignant pleural mesothelioma: a genome-wide association study.Acetate supplementation induces growth arrest of NG2/PDGFRα-positive oligodendroglioma-derived tumor-initiating cells Disturbance of autophagy-lysosome signaling molecule expression in human gastric adenocarcinoma Intermittent hypoxia selects for genotypes and phenotypes that increase survival, invasion, and therapy resistance The role of autophagy induced by tumor microenvironment in different cells and stages of cancer Metabolism and its sequelae in cancer evolution and therapy.Phosphorylation of the BNIP3 C-Terminus Inhibits Mitochondrial Damage and Cell Death without Blocking Autophagy.Simultaneous Hypoxia and Low Extracellular pH Suppress Overall Metabolic Rate and Protein Synthesis In Vitro Proton pump inhibitors for the treatment of cancer in companion animals.Extracellular pH Modulates Neuroendocrine Prostate Cancer Cell Metabolism and Susceptibility to the Mitochondrial Inhibitor Niclosamide.Autophagy is a protective mechanism for human melanoma cells under acidic stress.Acidosis Activates Endoplasmic Reticulum Stress Pathways through GPR4 in Human Vascular Endothelial Cells.Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane.GSH-dependent antioxidant defense contributes to the acclimation of colon cancer cells to acidic microenvironment Acid-mediated tumor proteolysis: contribution of cysteine cathepsins Two-wave nanotherapy to target the stroma and optimize gemcitabine delivery to a human pancreatic cancer model in mice Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity.Targeting pancreatic ductal adenocarcinoma acidic microenvironment Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine: implications for cancer therapies.Acidic tumor microenvironment and pH-sensing G protein-coupled receptors.Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors.Autophagy and cancer metabolism.Extracellular acidity, a "reappreciated" trait of tumor environment driving malignancy: perspectives in diagnosis and therapy.Responses and adaptations of intervertebral disc cells to microenvironmental stress: a possible central role of autophagy in the adaptive mechanism.Integrating autophagy and metabolism in cancer.Acid-sensing ion channels contribute to the effect of extracellular acidosis on proliferation and migration of A549 cells.Therapy-induced microenvironmental changes in cancer.

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Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments.

http://www.wikidata.org/entity/Q37111862

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 19 June 2012

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments.

@en

Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments.

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type

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Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments.

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Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments.

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prefLabel

Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments.

@en

Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments.

@nl

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0008-5472.CAN-11-3881

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Cancer Research

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Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments.

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Bonnie F Sloane

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Edward Haller

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Jennifer M Rothberg

http://www.w3.org/2001/XMLSchema#string

Jonathan W Wojtkowiak

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Joshua B Proemsey

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Karla J Schramm

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Mark C Lloyd

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Robert J Gillies

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Virendra Kumar

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P2860

The Hallmarks of Cancer

Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells

TOR signaling in growth and metabolism

A protein conjugation system essential for autophagy.

Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains

Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy

Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3.

Autophagic cell death: the story of a misnomer

mTOR regulation of autophagy

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

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3938-3947

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scholarly article

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10.1158/0008-5472.CAN-11-3881

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