Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6.
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An immunomodulatory role for the Mycobacterium tuberculosis region of difference 1 locus proteins PE35 (Rv3872) and PPE68 (Rv3873)The transcriptional regulator Rv0485 modulates the expression of a pe and ppe gene pair and is required for Mycobacterium tuberculosis virulenceNovel M tuberculosis antigen-specific T-cells are early markers of infection and disease progressionMycobacterial PE/PPE proteins at the host-pathogen interface.Whole genome identification of Mycobacterium tuberculosis vaccine candidates by comprehensive data mining and bioinformatic analysesImmunogenicity of the Mycobacterium tuberculosis PPE55 (Rv3347c) protein during incipient and clinical tuberculosis.Differential effects of prior exposure to environmental mycobacteria on vaccination with Mycobacterium bovis BCG or a recombinant BCG strain expressing RD1 antigens.Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulencePPE38 modulates the innate immune response and is required for Mycobacterium marinum virulence.Genomics and the evolution, pathogenesis, and diagnosis of tuberculosis.Serodiagnosis efficacy and immunogenicity of the fusion protein of Mycobacterium tuberculosis composed of the 10-kilodalton culture filtrate protein, ESAT-6, and the extracellular domain fragment of PPE68.Mycobacterial gene cloning and expression, comparative genomics, bioinformatics and proteomics in relation to the development of new vaccines and diagnostic reagents.Identifying and characterising PPE7 (Rv0354c) high activity binding peptides and their role in inhibiting cell invasion.Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence.Association of strong immune responses to PPE protein Rv1168c with active tuberculosis.Mycobacterium tuberculosis PPE68 and Rv2626c genes contribute to the host cell necrosis and bacterial escape from macrophagesScreening and assessing 11 Mycobacterium tuberculosis proteins as potential serodiagnostical markers for discriminating TB patients from BCG vaccinees.Polymorphic exact tandem repeat A (PETRA): a newly defined lineage of mycobacterium tuberculosis in israel originating predominantly in Sub-Saharan Africa.Mycobacterium tuberculosis evolutionary pathogenesis and its putative impact on drug development.Release of mycobacterial antigens.Comparative evaluation of MPT83 (Rv2873) for T helper-1 cell reactivity and identification of HLA-promiscuous peptides in Mycobacterium bovis BCG-vaccinated healthy subjectsIdentification of Mycobacterium tuberculosis PPE68-specific HLA-A*0201-restricted epitopes for tuberculosis diagnosis.Esx Systems and the Mycobacterial Cell Envelope: What's the Connection?Efficient testing of large pools of Mycobacterium tuberculosis RD1 peptides and identification of major antigens and immunodominant peptides recognized by human Th1 cells.Bioinformatics Identification of Drug Resistance-Associated Gene Pairs in Mycobacterium tuberculosis.Prevalence of Latent Tuberculosis Infection among Medical Students in South Korea.Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutininUse of enzyme-linked immunospot assay with Mycobacterium tuberculosis-specific peptides for diagnosis of recent infection with M. tuberculosis after accidental laboratory exposure.Generation of attenuated Mycobacterium bovis strains by signature-tagged mutagenesis for discovery of novel vaccine candidates.New insights into the host cell necrosis in tuberculosis.Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.Exploring the Contribution of Mycobacteria Characteristics in Their Interaction with Human MacrophagesThe PE and PPE Protein Families of Mycobacterium tuberculosis
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P2860
Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6.
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article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 2004
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Cell envelope protein PPE68 co ...... e filtrate protein and ESAT-6.
@en
Cell envelope protein PPE68 co ...... e filtrate protein and ESAT-6.
@nl
type
label
Cell envelope protein PPE68 co ...... e filtrate protein and ESAT-6.
@en
Cell envelope protein PPE68 co ...... e filtrate protein and ESAT-6.
@nl
prefLabel
Cell envelope protein PPE68 co ...... e filtrate protein and ESAT-6.
@en
Cell envelope protein PPE68 co ...... e filtrate protein and ESAT-6.
@nl
P2093
P2860
P1476
Cell envelope protein PPE68 co ...... e filtrate protein and ESAT-6.
@en
P2093
Caroline Demangel
Claude Leclerc
Laleh Majlessi
Paul J Cockle
Stewart T Cole
P2860
P304
P356
10.1128/IAI.72.4.2170-2176.2004
P407
P577
2004-04-01T00:00:00Z